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Product Details
OST00191W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4; alpha, beta, gamma isoforms) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPC4.
Target Information
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. TRPC4 forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4. The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7). Diseases associated with TRPC4 include Photosensitive Epilepsy.CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels. CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha TRPC4; beta TRPC4; beta-2 TRPC4; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; Short transient receptor potential channel 4; transient receptor potential cation channel, subfamily C, member 4; Trp-related protein 4; TRPC 4; TrpC4; Trpc4_v2
Gene Aliases: HTRP-4; HTRP4; TRP4; TRPC4
UniProt ID: (Human) Q9UBN4
Entrez Gene ID: (Human) 7223
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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