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Immunogen sequence: LIWRKHSASA LVLHGHNQNC DCSPDITLKI QFLRLLQSFS DHHENKYLLL NNQELNELSA ISLKANIPEV EAVLNTDRSL VCDGK
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: protein phosphatase 1, regulatory subunit 158; Protein TAP1; Protein TRUSS; short transient receptor potential channel 4 associated protein; Short transient receptor potential channel 4-associated protein; TAP1 protein; TNF-receptor; TNF-receptor ubiquitous scaffolding/signaling protein; TP4AP; transient receptor potential cation channel, subfamily C, member 4 associated protein; TRP4-associated protein; trpc4-associated protein; tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein
Gene Aliases: C20orf188; PPP1R158; TRPC4AP; TRRP4AP; TRUSS
UniProt ID: (Human) Q8TEL6
Entrez Gene ID: (Human) 26133
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