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Alomone Labs, LTD
TRPM2 Polyclonal Antibody, Atto™ 594
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FIGURE: 1 / 1
TRPM2 Antibody (ACC-043-AR-50UL) in IHC (F)
Expression of TRPM2 in rat lung - Immunohistochemical staining of rat lung frozen sections using Anti-TRPM2-ATTO Fluor-594 Antibody (#ACC-043-AR), (1:50). A. TRPM2 staining is specific for respiratory epithelium in the bronchi. B. Merged with bright field.
Product Details
ACC-043-AR-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HTFQGKEWDPKKHVQE,corresponding to amino acid residues 105-120 of mouse TRPM2, Intracellular, N-terminus
Conjugate
Excitation/Emission Max
602/622 nm
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.6.1.13; EREG 1; Estrogen-responsive element-associated gene 1 protein; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel, subfamily M, member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2
Gene Aliases: 9830168K16Rik; C79133; EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; Trp7; TRPC7; TRPM2; Trpm2-predicted; Trrp7
UniProt ID: (Human) O94759, (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Human) 7226, (Rat) 294329, (Mouse) 28240
manganese ion transport
metabolic process
response to hydroperoxide
manganese ion transmembrane transport
transport
ion transport
cation transport
sodium ion transport
calcium ion transport
response to oxidative stress
positive regulation of insulin secretion
ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
calcium ion import across plasma membrane
positive regulation of oxidative stress-induced neuron death
sodium ion transmembrane transport
estrous cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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