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Invitrogen
TRPM2 Polyclonal Antibody
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FIGURE: 1 / 5
TRPM2 Antibody (PA5-119946) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat cerebellum tissue using TRPM2 Polyclonal Antibody (Product # PA5-119946). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the TRPM2 antibody at a dilution of 1:... View More
Product Details
PA5-119946
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse TRPM2 aa 100-150/1503 (Cytoplasmic)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913518
Product Specific Information
Positive Control: THP-1 cell lysate, PC-3 cell lysate, rat cerebellum tissue, human bone tissue, mouse brain tissue, SH-SY5Y.
Subcellular Location: Lysosome, cell membrane, perikaryon, cell projection, cytoplasmic vesicle.
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.6.1.13; EREG 1; Estrogen-responsive element-associated gene 1 protein; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel, subfamily M, member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2
Gene Aliases: 9830168K16Rik; C79133; EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; Trp7; TRPC7; TRPM2; Trpm2-predicted; Trrp7
UniProt ID: (Human) O94759, (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Human) 7226, (Rat) 294329, (Mouse) 28240
manganese ion transport
metabolic process
response to hydroperoxide
manganese ion transmembrane transport
transport
ion transport
cation transport
sodium ion transport
calcium ion transport
response to oxidative stress
positive regulation of insulin secretion
ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
calcium ion import across plasma membrane
positive regulation of oxidative stress-induced neuron death
sodium ion transmembrane transport
estrous cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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