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Invitrogen
TRPM4 Humanized Recombinant Human Monoclonal Antibody (SAA0760)
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TRPM4 Humanized Antibody (MA5-54713) in WB
Western blot analysis using TRPM4 Humanized monoclonal antibody (Product # MA5-54713) at a dilution of 1 μg/mL. Lane 1: Jurkat cell lysate Lane 2: PC12 cell lysate Lane 3: 23T cell lysate. Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP at 0.1 μg/mL. Predict MW: 134 kDa Observed MW: 134 kDa.
Product Details
MA5-54713
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ VHH-hFc
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA0760
Immunogen
Recombinant Human TRPM4/LTRPC4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_3666961
Product Specific Information
Compatible with Direct ELISA
Target Information
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LTrpC-4; Melastatin-4; Transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4
Gene Aliases: hTRPM4; LTRPC4; PFHB1B; TRPM4; TRPM4B
UniProt ID: (Human) Q8TD43
Entrez Gene ID: (Human) 54795
adaptive immune response
dendritic cell chemotaxis
regulation of T cell cytokine production
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
protein sumoylation
negative regulation of bone mineralization
sodium ion transmembrane transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
vasoconstriction
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of vasoconstriction
cardiac conduction
calcium ion transmembrane transport
positive regulation of canonical Wnt signaling pathway
positive regulation of atrial cardiac muscle cell action potential
positive regulation of adipose tissue development
positive regulation of regulation of vascular smooth muscle cell membrane depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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