Alomone Labs, LTD

TRPP1 (PKD2) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

ACC-052-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)ERWESDDAASQISH, corresponding to amino acid residues 914-927 of human TRPP1, Intracellular, C-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A MGC138466; Autosomal dominant polycystic kidney disease type II protein; MGC138468; PC2; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 homolog; Polycystic kidney disease 2 protein; Polycystic kidney disease 2 protein homolog; polycystin 2; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2; TRPP1

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Gene Aliases: APKD2; C030034P18Rik; Pc-2; PC2; PKD2; PKD4; RGD1559992; TRPP1; TRPP2

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UniProt ID: (Human) Q13563, (Mouse) O35245

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Entrez Gene ID: (Human) 5311, (Rat) 498328, (Mouse) 18764

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Function(s)
receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity potassium channel activity calcium ion binding protein binding cytoskeletal protein binding voltage-gated cation channel activity identical protein binding protein homodimerization activity actinin binding HLH domain binding ion channel binding calcium-induced calcium release activity ATPase binding phosphoprotein binding muscle alpha-actinin binding calcium channel activity channel activity alpha-actinin binding metal ion binding
Process(es)
branching involved in ureteric bud morphogenesis liver development embryonic placenta development heart looping detection of nodal flow calcium ion transport cell cycle arrest JAK-STAT cascade determination of left/right symmetry heart development negative regulation of cell proliferation spinal cord development neural tube development regulation of cAMP metabolic process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle cellular response to reactive oxygen species metanephric part of ureteric bud development sodium ion transmembrane transport aorta development regulation of cell proliferation cytoplasmic sequestering of transcription factor positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter detection of mechanical stimulus release of sequestered calcium ion into cytosol centrosome duplication regulation of postsynaptic membrane potential negative regulation of ryanodine-sensitive calcium-release channel activity placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport positive regulation of cell cycle arrest cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis regulation of calcium ion import negative regulation of G1/S transition of mitotic cell cycle kidney development cellular calcium ion homeostasis positive regulation of cytosolic calcium ion concentration positive regulation of gene expression transmembrane transport renal system development transport ion transport
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