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TRPS1 Antibody (CF813180) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPS1 (RC215856, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRPS1 (1:500).
Product Details
CF813180
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI8C11
Immunogen
Human recombinant protein fragment corresponding to amino acids 985-1281 of human TRPS1 (NP_054831) produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 8% trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tricho-rhino-phalangeal syndrome type I protein; trichorhinophalangeal syndrome I; trichorhinophalangeal syndrome I homolog; Zinc finger protein GC79; Zinc finger transcription factor Trps1
Gene Aliases: AI115454; AI447310; D15Ertd586e; GC79; LGCR; TRPS1
UniProt ID: (Human) Q9UHF7
Entrez Gene ID: (Human) 7227, (Mouse) 83925, (Rat) 299897
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
DNA binding
sequence-specific DNA binding
metal ion binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
chondrocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of histone deacetylation
regulation of chondrocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
biological_process
skeletal system development
transcription from RNA polymerase II promoter
NLS-bearing protein import into nucleus
heart development
organ morphogenesis
tissue development
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
cell development
digestive tract development
anatomical structure formation involved in morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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