Alomone Labs, LTD

TRPV4 Polyclonal Antibody, Atto™ 550

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

ACC-034-AO-50UL

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

1:20
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDGHQQGYAPKWRAEDAPL, corresponding to amino acid residues 853-871 of rat TRPV4, Intracellular, C-terminus
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Conjugate

Atto™ 550 Atto™ 550 Atto™ 550

Excitation/Emission Max

554/575 nm

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Osm-9-like TRP channel 4; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; TRP12; TrpV4; trpv4 channel; Vanilloi; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; vanilloid receptor-related osmotically activated channel (Vroac); Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2

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Gene Aliases: 0610033B08Rik; BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; TRPV4; VR-OAC; VRL-2; VRL2; VROAC

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UniProt ID: (Human) Q9HBA0, (Mouse) Q9EPK8, (Rat) Q9ERZ8

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Entrez Gene ID: (Human) 59341, (Mouse) 63873, (Rat) 66026

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Function(s)
actin binding osmosensor activity protein kinase C binding cation channel activity calcium channel activity protein binding calmodulin binding ATP binding microtubule binding stretch-activated, cation-selective, calcium channel activity protein kinase binding SH2 domain binding alpha-tubulin binding beta-tubulin binding actin filament binding nucleotide binding ion channel activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter diet induced thermogenesis calcium ion transport cellular calcium ion homeostasis cell volume homeostasis actin filament organization cell-cell junction assembly positive regulation of cytosolic calcium ion concentration osmosensory signaling pathway response to mechanical stimulus positive regulation of gene expression positive regulation of macrophage chemotaxis negative regulation of neuron projection development vasopressin secretion positive regulation of microtubule depolymerization actin cytoskeleton reorganization response to insulin cellular response to heat hyperosmotic salinity response glucose homeostasis positive regulation of vascular permeability cortical microtubule organization positive regulation of JNK cascade microtubule polymerization regulation of response to osmotic stress positive regulation of inflammatory response multicellular organismal water homeostasis positive regulation of ERK1 and ERK2 cascade calcium ion import calcium ion transmembrane transport cellular response to osmotic stress cellular hypotonic response cellular hypotonic salinity response positive regulation of monocyte chemotactic protein-1 production positive regulation of macrophage inflammatory protein 1 alpha production positive regulation of chemokine (C-C motif) ligand 5 production blood vessel endothelial cell delamination negative regulation of brown fat cell differentiation signal transduction involved in regulation of aerobic respiration positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of energy homeostasis positive regulation of interleukin-6 secretion transport ion transport response to osmotic stress hypotonic response transmembrane transport
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