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Product Details
BS-13146R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TRRAP, amino acids 3401-3600.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TRRAP is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. TRRAP plays a central role in MYC transcription activation, and also participates in cell transformation by MYC is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. TRRAP probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation, however, it is probably not required in the steps following histone acetylation in processes of transcription activation. TRRAP may be required for the mitotic checkpoint and normal cell cycle progression. TRRAP is a component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 350/400 kDa PCAF-associated factor; OTTHUMP00000197294; OTTHUMP00000197295; PAF350/400; STAF40; Tra1 homolog; transactivation/transformation-domain associated protein; Transformation/transcription domain-associated protein
Gene Aliases: AI481500; PAF350/400; PAF400; STAF40; TR-AP; Tra1; TRRAP
UniProt ID: (Human) Q9Y4A5
Entrez Gene ID: (Human) 8295, (Mouse) 100683
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
phosphorylation
histone acetylation
histone deubiquitination
histone H4 acetylation
histone H2A acetylation
beta-catenin-TCF complex assembly
mitotic cell cycle checkpoint
chromatin modification
regulation of nucleic acid-templated transcription
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