Proteintech

TRX2 Polyclonal Antibody

TRX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

TRX2 Antibody (13089-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer using 13089-1-AP (TRX2 antibody) at dilution of 1:100 (under 10x lens).

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Product Details

13089-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRX2 Fusion Protein Ag3640 (1-166 aa encoded by BC013726)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAQRLLLRR FLASVISRKP SQGQWPPLTS RALQTPQCSP GGLTVTPNPA RTIYTTRISL TTFNIQDGPD FQDRVVNSET PVVVDFHAQW CGPCKILGPR LEKMVAKQHG KVVMAKVDID DHTDLAIEYE VSAVPTVLAM KNGDVVDKFV GIKDEDQLEA FLKKLIG (1-166 aa encoded by BC013726)

Target Information

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.

Free radical biology & medicine

Prutton KM,Marentette JO,Leifheit BA,Esquer H,LaBarbera DV,Anderson CC,Maclean KN,Roede JR

Wed Jun 01 00:00:00 UTC 2022

TRX2/Rab35 Interaction Impairs Exosome Secretion by Inducing Rab35 Degradation.

International journal of molecular sciences

Zhang T,Zhao L,Han L,Li Y,Hu L,Wang H,Zou F

Sun Jun 12 00:00:00 UTC 2022

Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.

Antioxidants (Basel, Switzerland)

Liu S,Wen X,Huang Q,Zhu M,Lu J

Fri Jun 10 00:00:00 UTC 2022

Compartmentally scavenging hepatic oxidants through AMPK/SIRT3-PGC1α axis improves mitochondrial biogenesis and glucose catabolism.

Free radical biology & medicine

Wu M,Zhang C,Xie M,Zhen Y,Lai B,Liu J,Qiao L,Liu S,Shi D

Thu May 20 00:00:00 UTC 2021

Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.

Journal of neurochemistry

Li KY,Xiang XJ,Song L,Chen J,Luo B,Wen QX,Zhong BR,Zhou GF,Deng XJ,Ma YL,Hu LT,Chen GJ

Sat May 01 00:00:00 UTC 2021

Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.

Journal of neurochemistry

Li KY,Xiang XJ,Song L,Chen J,Luo B,Wen QX,Zhong BR,Zhou GF,Deng XJ,Ma YL,Hu LT,Chen GJ

Sat May 01 00:00:00 UTC 2021

Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.

Journal of neurochemistry

Li KY,Xiang XJ,Song L,Chen J,Luo B,Wen QX,Zhong BR,Zhou GF,Deng XJ,Ma YL,Hu LT,Chen GJ

Sat May 01 00:00:00 UTC 2021

Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.

Journal of neurochemistry

Li KY,Xiang XJ,Song L,Chen J,Luo B,Wen QX,Zhong BR,Zhou GF,Deng XJ,Ma YL,Hu LT,Chen GJ

Sat May 01 00:00:00 UTC 2021

Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis.

Molecular therapy. Nucleic acids

Zeng N,Huang YQ,Yan YM,Hu ZQ,Zhang Z,Feng JX,Guo JS,Zhu JN,Fu YH,Wang XP,Zhang MZ,Duan JZ,Zheng XL,Xu JD,Shan ZX

Fri Dec 03 00:00:00 UTC 2021

Combination Treatment with Methylene Blue and Hypothermia in Global Cerebral Ischemia.

Molecular neurobiology

Li L,Yang R,Li P,Lu H,Hao J,Li L,Tucker D,Zhang Q

Thu Mar 01 00:00:00 UTC 2018

Combination Treatment with Methylene Blue and Hypothermia in Global Cerebral Ischemia.

Molecular neurobiology

Li L,Yang R,Li P,Lu H,Hao J,Li L,Tucker D,Zhang Q

Thu Mar 01 00:00:00 UTC 2018

Anthocyanins inhibit high glucose-induced renal tubular cell apoptosis caused by oxidative stress in db/db mice.

International journal of molecular medicine

Wei J,Wu H,Zhang H,Li F,Chen S,Hou B,Shi Y,Zhao L,Duan H

Thu Mar 01 00:00:00 UTC 2018

Anthocyanins inhibit high glucose-induced renal tubular cell apoptosis caused by oxidative stress in db/db mice.

International journal of molecular medicine

Wei J,Wu H,Zhang H,Li F,Chen S,Hou B,Shi Y,Zhao L,Duan H

Thu Mar 01 00:00:00 UTC 2018

Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.

Experimental and molecular pathology

Petersen DR,Orlicky DJ,Roede JR,Shearn CT

Wed Aug 01 00:00:00 UTC 2018

Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.

Medicine and science in sports and exercise

Wu C,Yang L,Tucker D,Dong Y,Zhu L,Duan R,Liu TC,Zhang Q

Tue May 01 00:00:00 UTC 2018

Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.

International journal of medical sciences

Xin X,Dang H,Zhao X,Wang H

Mon May 21 00:00:00 UTC 2018

Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.

International journal of medical sciences

Xin X,Dang H,Zhao X,Wang H

Mon May 21 00:00:00 UTC 2018

Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions.

International journal of molecular sciences

Shen W,Yau B,Lee SR,Zhu L,Yam M,Gillies MC

Wed Mar 01 00:00:00 UTC 2017

Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions.

International journal of molecular sciences

Shen W,Yau B,Lee SR,Zhu L,Yam M,Gillies MC

Wed Mar 01 00:00:00 UTC 2017

Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.

Free radical biology & medicine

Dong K,Wu M,Liu X,Huang Y,Zhang D,Wang Y,Yan LJ,Shi D

Thu Dec 01 00:00:00 UTC 2016

Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.

Free radical biology & medicine

Dong K,Wu M,Liu X,Huang Y,Zhang D,Wang Y,Yan LJ,Shi D

Thu Dec 01 00:00:00 UTC 2016

Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model.

Journal of Alzheimer's disease : JAD

Aso E,Andrés-Benito P,Ferrer I

Tue Oct 04 00:00:00 UTC 2016

Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model.

Journal of Alzheimer's disease : JAD

Aso E,Andrés-Benito P,Ferrer I

Tue Oct 04 00:00:00 UTC 2016

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.

Scientific reports

Li P,Zhang D,Shen L,Dong K,Wu M,Ou Z,Shi D

Wed Mar 09 00:00:00 UTC 2016

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.

Scientific reports

Li P,Zhang D,Shen L,Dong K,Wu M,Ou Z,Shi D

Wed Mar 09 00:00:00 UTC 2016

Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.

American journal of physiology. Renal physiology

Hou Y,Li S,Wu M,Wei J,Ren Y,Du C,Wu H,Han C,Duan H,Shi Y

Tue Mar 15 00:00:00 UTC 2016

Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.

American journal of physiology. Renal physiology

Hou Y,Li S,Wu M,Wei J,Ren Y,Du C,Wu H,Han C,Duan H,Shi Y

Tue Mar 15 00:00:00 UTC 2016

G6PD protects from oxidative damage and improves healthspan in mice.

Nature communications

Nóbrega-Pereira S,Fernandez-Marcos PJ,Brioche T,Gomez-Cabrera MC,Salvador-Pascual A,Flores JM,Viña J,Serrano M

Tue Mar 15 00:00:00 UTC 2016

G6PD protects from oxidative damage and improves healthspan in mice.

Nature communications

Nóbrega-Pereira S,Fernandez-Marcos PJ,Brioche T,Gomez-Cabrera MC,Salvador-Pascual A,Flores JM,Viña J,Serrano M

Tue Mar 15 00:00:00 UTC 2016

The FEBS journal

Sun HY,Hu YJ,Zhao XY,Zhong Y,Zeng LL,Chen XB,Yuan J,Wu J,Sun Y,Kong W,Kong WJ

Wed Jul 01 00:00:00 UTC 2015

The FEBS journal

Sun HY,Hu YJ,Zhao XY,Zhong Y,Zeng LL,Chen XB,Yuan J,Wu J,Sun Y,Kong W,Kong WJ

Wed Jul 01 00:00:00 UTC 2015

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice.

Journal of Alzheimer's disease : JAD

Aso E,Sánchez-Pla A,Vegas-Lozano E,Maldonado R,Ferrer I

Fri Aug 21 00:00:00 UTC 2015

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice.

Journal of Alzheimer's disease : JAD

Aso E,Sánchez-Pla A,Vegas-Lozano E,Maldonado R,Ferrer I

Fri Aug 21 00:00:00 UTC 2015

Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death.

Free radical biology & medicine

Arodin L,Miranda-Vizuete A,Swoboda P,Fernandes AP

Fri Aug 01 00:00:00 UTC 2014

Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death.

Free radical biology & medicine

Arodin L,Miranda-Vizuete A,Swoboda P,Fernandes AP

Fri Aug 01 00:00:00 UTC 2014

Alteration of thioredoxin and glutaredoxin in the progression of Alzheimer's disease.

Journal of Alzheimer's disease : JAD

Arodin L,Lamparter H,Karlsson H,Nennesmo I,Björnstedt M,Schröder J,Fernandes AP

Thu Oct 30 00:00:00 UTC 2014

Alteration of thioredoxin and glutaredoxin in the progression of Alzheimer's disease.

Journal of Alzheimer's disease : JAD

Arodin L,Lamparter H,Karlsson H,Nennesmo I,Björnstedt M,Schröder J,Fernandes AP

Thu Oct 30 00:00:00 UTC 2014

Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.

Longevity & healthspan

Brown-Borg HM,Rakoczy S,Wonderlich JA,Armstrong V,Rojanathammanee L

Tue Jan 13 00:00:00 UTC 2015

Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.

Longevity & healthspan

Brown-Borg HM,Rakoczy S,Wonderlich JA,Armstrong V,Rojanathammanee L

Tue Jan 13 00:00:00 UTC 2015

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

Cell reports

Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D

Thu May 30 00:00:00 UTC 2013

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

Cell reports

Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D

Thu May 30 00:00:00 UTC 2013

TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens.

PloS one

Brennan LA,Lee W,Kantorow M

Thu Nov 04 00:00:00 UTC 2010

TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens.

PloS one

Brennan LA,Lee W,Kantorow M

Thu Nov 04 00:00:00 UTC 2010

TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens.

PloS one

Brennan LA,Lee W,Kantorow M

Thu Nov 04 00:00:00 UTC 2010

TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens.

PloS one

Brennan LA,Lee W,Kantorow M

Thu Nov 04 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: mitochondrial thioredoxin; mt-Trx; MTRX; thioredoxin nuclear gene encoding mitochondrial protein; Thioredoxin, mitochondrial; Thioredoxin-2; Thioredoxin2; TRX-2

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Gene Aliases: 2510006J11Rik; AI788873; COXPD29; MT-TRX; MTRX; TRX2; TXN2

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UniProt ID: (Human) Q99757, (Mouse) P97493, (Rat) P97615

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Entrez Gene ID: (Human) 25828, (Mouse) 56551, (Rat) 79462

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Function(s)

protein binding peptide-methionine (S)-S-oxide reductase activity protein disulfide oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor protein complex binding peptide-methionine (R)-S-oxide reductase activity

Process(es)

sulfate assimilation protein folding glycerol ether metabolic process transport cellular response to oxidative stress cell redox homeostasis oxidation-reduction process response to hypoxia response to oxidative stress response to nutrient response to hormone response to glucose response to organic cyclic compound cellular response to nutrient levels response to drug response to axon injury response to reactive oxygen species

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRX2 Polyclonal Antibody

TRX2 Antibody (13089-1-AP) in IHC (P)

Product Details

13089-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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