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Product Details
PA5-54147
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TSCOT. Recombinant protein control fragment (Product #RP-92924).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648985
Product Specific Information
Immunogen sequence: KVPESVAKPS QELPAVDTVS GTVGTYRTLD PDQLDQQYAV GHPPSPGKAK PH
Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 62%.
Target Information
The TSCOT gene, known as the Thymic Stromal Co-transporter, plays a crucial role in the gene expression regulation within thymic epithelial cells, essential for T cell development. It encodes a protein that bears weak homology to bacterial 12 transmembrane co-transporters. Research indicates that TSCOT is predominantly expressed in thymic tissues, although low levels of expression are detectable in other epithelial tissues such as skin and lungs. The gene has been co-analyzed with Foxn1 and Hoxa3, highlighting its significant role in organogenesis. Studies utilizing competitive reverse transcription-polymerase chain reaction (RT-PCR) have mapped TSCOT to specific genomic regions, verifying its expression in a tissue and cell-type specific manner. The introduction of a neoantigen into TSCOT-expressing cells demonstrates its capability to mediate antigen-specific T cell tolerance, offering potential applications in immunological therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Solute carrier family 46 member 2; solute carrier family 46, member 2; thymic stromal co-transporter; Thymic stromal cotransporter homolog
Gene Aliases: Ly110; SLC46A2; TSCOT
UniProt ID: (Human) Q9BY10
Entrez Gene ID: (Human) 57864
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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