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TSEN15 Antibody (PA5-68435) in IHC (P)
Immunohistochemical analysis of TSEN15 in paraffin-embedded Human colorectal cancer tissue using (left) TSEN15 Polyclonal Antibody (Product # PA5-68435) at a 1:85 dilution and (right) is treated with fusion protein. (Original magnification: x200).
Product Details
PA5-68435
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length Fusion protein of human TSEN15
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2692243
Target Information
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsSEN15; SEN15 homolog; tRNA splicing endonuclease 15 homolog; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15; TSEN15 tRNA splicing endonuclease subunit
Gene Aliases: 5730449L18Rik; AL023077; C1orf19; PCH2F; SEN15; TSEN15
UniProt ID: (Human) Q8WW01, (Mouse) Q8R3W5
Entrez Gene ID: (Human) 116461, (Mouse) 66637
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