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Product Details
13103-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TSEN2 Fusion Protein Ag3742 (159-465 aa encoded by BC019582)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SNMEGTAGG ERPSVVNGDS GKSGGVGDPR EPLGCLQEGS GCHPTTESFE KSVREDASPL PHVCCCKQDA LILQRGLHHE DGSQHIGLLH PGDRGPDHEY VLVEEAECAM SEREAAPNEE LVQRNRLICR RNPYRIFEYL QLSLEEAFFL VYALGCLSIY YEKEPLTIVK LWKAFTVVQP TFRTTYMAYH YFRSKGWVPK VGLKYGTDLL LYRKGPPFYH ASYSVIIELV DDHFEGSLRR PLSWKSLAAL SRVSVNVSKE LMLCYLIKPS TMTDKEMESP ECMKRIKVQE VILSRWVSSR ERSDQDDL (159-465 aa encoded by BC019582)
Target Information
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HsSen2; tRNA-intron endonuclease Sen2; tRNA-intron nuclease 2; tRNA-splicing endonuclease subunit Sen2; TSEN2 tRNA splicing endonuclease subunit
Gene Aliases: AU067695; PCH2B; RGD1309946; SEN2; SEN2L; TSEN2
UniProt ID: (Human) G5E9Q3, (Rat) Q5M954, (Mouse) Q6P7W5
Entrez Gene ID: (Human) 80746, (Rat) 312649, (Mouse) 381802
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