Proteintech

TSG101 Monoclonal Antibody (2B7G8)

TSG101 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

TSG101 Antibody (67381-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using 67381-1-Ig (TSG101 antibody), at dilution of 1:2000 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

TSG101 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TSG101 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

67381-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:20,000

View 16 publications 16 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

Immunocytochemistry (ICC/IF)

1:2,000

Flow Cytometry (Flow)

0.5 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2B7G8

Immunogen

TSG101 Fusion Protein Ag28569

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

TSG101-4A10 recognizes TSG101 protein, the product of a recently identified Tumor Susceptibility Gene whose inactivation in mouse fibroblasts results in cell transformation and the ability of those cells to form tumors in nude mice. The TSG101 gene encodes a 46 kDa protein and contains a proline-rich domain and a leucine-zipper motif within a coiled-coil domain near the carboxyl terminus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lu L,Zi H,Zhou J,Huang J,Deng Z,Tang Z,Li L,Shi X,Lo PC,Lovell JF,Deng D,Wan C,Jin H

Wed Mar 01 00:00:00 UTC 2023

Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.

Thoracic cancer

Peng X,Zhao L,Yao L,Dong J,Wu W,Luo T

Sat Jul 01 00:00:00 UTC 2023

Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD/R-Treated Microglia via the GPR30-TLR4-NF-κB Axis.

Neurochemical research

Peng J,Yu Z,Xiao R,Hu X,Xia Y

Thu Jun 01 00:00:00 UTC 2023

Circulating Exosomal miR-181b-5p Promoted Cell Senescence and Inhibited Angiogenesis to Impair Diabetic Foot Ulcer via the Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway.

Frontiers in cardiovascular medicine

Wang S,Shi M,Zhou J,Wang W,Zhang Y,Li Y

Tue May 10 00:00:00 UTC 2022

Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway.

Cellular & molecular biology letters

Liang Z,Liu L,Gao R,Che C,Yang G

Sun Oct 09 00:00:00 UTC 2022

Exosomes Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation through the Wnt3a/β-Catenin Signaling Pathway.

Oxidative medicine and cellular longevity

Li J,Zhao B,Dai Y,Zhang X,Chen Y,Wu X

Mon Nov 21 00:00:00 UTC 2022

Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma.

Journal of clinical laboratory analysis

Huang X,Zhou H,Yang X,Shi W,Hu L,Wang J,Zhang F,Shao F,Zhang M,Jiang F,Wang Y

Thu Dec 01 00:00:00 UTC 2022

Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.

Bioactive materials

Luo L,Gong J,Wang Z,Liu Y,Cao J,Qin J,Zuo R,Zhang H,Wang S,Zhao P,Yang D,Zhang M,Wang Y,Zhang J,Zhou Y,Li C,Ni B,Tian Z,Liu M

Thu Sep 01 00:00:00 UTC 2022

Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway.

International journal of biological macromolecules

Zhao B,Li J,Zhang X,Dai Y,Yang N,Bao Z,Chen Y,Wu X

Sun May 15 00:00:00 UTC 2022

Adipose-Derived Circulating Exosomes Promote Protection of the Pulmonary Endothelial Barrier by Inhibiting EndMT and Oxidative Stress through Down-Regulation of the TGF-β Pathway: A Potential Explanation for the Obesity Paradox in ARDS.

Oxidative medicine and cellular longevity

Qi D,Deng W,Chen X,Fan S,Peng J,Tang X,Wang D,Yu Q

Tue May 17 00:00:00 UTC 2022

Safety and biodistribution of exosomes derived from human induced pluripotent stem cells.

Frontiers in bioengineering and biotechnology

Gu Z,Yin Z,Song P,Wu Y,He Y,Zhu M,Wu Z,Zhao S,Huang H,Wang H,Tong C,Qi Z

Tue Sep 13 00:00:00 UTC 2022

Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1.

Frontiers in pharmacology

Zhou J,Wang Y,Zhang L,Chen Q,Zhu X,Jiang P,Jiang N,Zhao W,Li B

Sat Jul 16 00:00:00 UTC 2022

Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3.

Frontiers in oncology

Yuan H,Chen B,Chai R,Gong W,Wan Z,Zheng B,Hu X,Guo Y,Gao S,Dai Q,Yu P,Tu S

Tue Oct 25 00:00:00 UTC 2022

Endothelial cell-derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway.

Aging

Wang S,Shi M,Li J,Zhang Y,Wang W,Xu P,Li Y

Fri Dec 10 00:00:00 UTC 2021

Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612.

Journal of nanobiotechnology

Ge L,Xun C,Li W,Jin S,Liu Z,Zhuo Y,Duan D,Hu Z,Chen P,Lu M

Sun Nov 21 00:00:00 UTC 2021

Proteomics Analysis of Exosomes From Patients With Active Tuberculosis Reveals Infection Profiles and Potential Biomarkers.

Frontiers in microbiology

Zhang M,Xie Y,Li S,Ye X,Jiang Y,Tang L,Wang J

Tue Jan 25 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: ESCRT-I complex subunit TSG101; ESCRTI complex subunit TSG101; TSG 101; Tumor supressor; tumor susceptibility gene 10; tumor susceptibility gene 101; Tumor susceptibility gene 101 protein; tumor susceptibility protein

View more View less

Gene Aliases: AI255943; CC2; Rw; TSG10; TSG101; VPS23

View more View less

UniProt ID: (Human) Q99816, (Rat) Q6IRE4, (Mouse) Q61187

View more View less

Entrez Gene ID: (Human) 7251, (Rat) 292925, (Mouse) 22088

View more View less

Function(s)

DNA binding transcription corepressor activity protein binding ligand-dependent nuclear receptor transcription coactivator activity ubiquitin protein ligase binding protein homodimerization activity ubiquitin binding virion binding calcium-dependent protein binding

Process(es)

regulation of cell growth protein monoubiquitination autophagy cell cycle arrest negative regulation of cell proliferation endosome to lysosome transport protein transport endosomal transport viral life cycle keratinocyte differentiation multivesicular body assembly viral budding via host ESCRT complex ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway regulation of MAP kinase activity negative regulation of transcription, DNA-templated viral budding positive regulation of viral process cell division intracellular transport of virus autophagosome maturation regulation of viral release from host cell positive regulation of viral release from host cell positive regulation of exosomal secretion regulation of extracellular exosome assembly regulation of viral budding via host ESCRT complex positive regulation of viral budding via host ESCRT complex positive regulation of ubiquitin-dependent endocytosis cellular protein modification process cell differentiation regulation of growth regulation of nucleic acid-templated transcription transport cell cycle viral process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TSG101 Monoclonal Antibody (2B7G8)

TSG101 Antibody (67381-1-IG) in ICC/IF

Product Details

67381-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!