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Alomone Labs, LTD
TSH Receptor (TSHR) (extracellular) Polyclonal Antibody, Atto™ 488
FIGURE: 1 / 1
TSH Receptor (TSHR) (extracellular) Antibody (ATR-006-AG-50UL) in IHC
Expression of TSH receptor in mouse brain - Immunohistochemical staining of TSHR in mouse brain sections using Anti-TSH Receptor (TSHR) (extracellular)-ATTO Fluor-488 Antibody (#ATR-006-AG), (1:60). A. In the cerebellum, TSHR staining (green) appears in the molecular layer (MOL) and purkinje (P) layer. B. In the hippocampus, staining appears in CA3 pyramidal layer (P), (arrows). Nuclei are stained using DAP... View More
Product Details
ATR-006-AG-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ETLQAFDSHYDYTVC, corresponding to amino acid residues 376-390 of rat TSHR, Extracellular, N-terminus
Conjugate
Excitation/Emission Max
501/523 nm
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R
Gene Aliases: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; pet; TSHR; TSHRA
UniProt ID: (Human) P16473, (Mouse) P47750, (Rat) P21463
Entrez Gene ID: (Human) 7253, (Mouse) 22095, (Rat) 25360
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cell proliferation
adult locomotory behavior
hormone-mediated signaling pathway
B cell differentiation
thyroid-stimulating hormone signaling pathway
regulation of locomotion
positive regulation of multicellular organism growth
inner ear receptor cell development
inner ear receptor stereocilium organization
dopaminergic neuron differentiation
cochlea morphogenesis
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cell-cell signaling
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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