Proteintech

TSHR Polyclonal Antibody

FIGURE: 1 / 4

TSHR Antibody (14450-1-AP) in WB

HeLa cells were subjected to SDS PAGE followed by western blot with (Product # 14450-1-AP) (TSHR antibody) at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

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Product Details

14450-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TSHR Fusion Protein Ag5957 (1-253 aa encoded by BC063613)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This rabbit polyclonal antibody raised against N-terminal region (1-253 aa) of human TSHR can detect subunit A with an experimentally determined molecular weight of 62-70 kDa under reducing condition.

Immunogen sequence: MRPADLLQL VLLLDLPRDL GGMGCSSPPC ECHQEEDFRV TCKDIQRIPS LPPSTQTLKL IETHLRTIPS HAFSNLPNIS RIYVSIDVTL QQLESHSFYN LSKVTHIEIR NTRNLTYIDP DALKELPLLK FLGIFNTGLK MFPDLTKVYS TDIFFILEIT DNPYMTSIPV NAFQGLCNET LTLKLYNNGF TSVQGYAFNG TKLDAVYLNK NKYLTVIDKD AFGGVYSGPS LLLPLGRKSL SFETQKAPRS SMPS (1-253 aa encoded by BC063613)

Target Information

TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sinomenine Hydrochloride Promotes TSHR-Dependent Redifferentiation in Papillary Thyroid Cancer.

International journal of molecular sciences

Zhang J,Zhao A,Jia X,Li X,Liang Y,Liu Y,Xie X,Qu X,Wang Q,Zhang Y,Gao R,Yu Y,Yang A

Wed Sep 14 00:00:00 UTC 2022

Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation.

Environmental toxicology and pharmacology

Xu Q,Zhou L,Ri H,Li X,Zhang X,Qi W,Ye L

Tue Nov 01 00:00:00 UTC 2022

TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.

Oxidative medicine and cellular longevity

Fan J,Pan Q,Gao Q,Li W,Xiao F,Guo L

Tue Feb 08 00:00:00 UTC 2022

Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF^V600E by synergistically decreasing global trimethylation of H3K27.

Journal of cellular and molecular medicine

Fu H,Cheng L,Sa R,Jin Y,Chen L

Sun Mar 01 00:00:00 UTC 2020

Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening.

Cancers

Sondorp LHJ,Ogundipe VML,Groen AH,Kelder W,Kemper A,Links TP,Coppes RP,Kruijff S

Sat Oct 31 00:00:00 UTC 2020

A somatic mutation of RasGRP3 decreases Na⁺/I^- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.

American journal of cancer research

Song J,Qiu W,Deng X,Qiu Z,Fan Y,Yang Z

Wed Sep 30 00:00:00 UTC 2020

A somatic mutation of RasGRP3 decreases Na⁺/I^- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.

American journal of cancer research

Song J,Qiu W,Deng X,Qiu Z,Fan Y,Yang Z

Wed Sep 30 00:00:00 UTC 2020

Acute exposure of zebrafish embryo (Danio rerio) to flutolanil reveals its developmental mechanism of toxicity via disrupting the thyroid system and metabolism.

Environmental pollution (Barking, Essex : 1987)

Teng M,Zhu W,Wang D,Yan J,Qi S,Song M,Wang C

Thu Nov 01 00:00:00 UTC 2018

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves' disease.

Journal of translational medicine

Chen X,Huang F,Qi Y,Zhou M,Yin Q,Peng Y,Zhou Y,Ning G,Wang S

Thu Jul 05 00:00:00 UTC 2018

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves' disease.

Journal of translational medicine

Chen X,Huang F,Qi Y,Zhou M,Yin Q,Peng Y,Zhou Y,Ning G,Wang S

Thu Jul 05 00:00:00 UTC 2018

Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by Suppressing TNRC6C Expression.

Frontiers in endocrinology

Muhanhali D,Zhai T,Jiang J,Ai Z,Zhu W,Ling Y

Sat Apr 09 00:00:00 UTC 2022

Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.

Theranostics

Wei WJ,Sun ZK,Shen CT,Song HJ,Zhang XY,Qiu ZL,Luo QY

Mon Oct 23 00:00:00 UTC 2017

Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.

Theranostics

Wei WJ,Sun ZK,Shen CT,Song HJ,Zhang XY,Qiu ZL,Luo QY

Mon Oct 23 00:00:00 UTC 2017

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.

Oncotarget

Cheng L,Jin Y,Liu M,Ruan M,Chen L

Tue Mar 21 00:00:00 UTC 2017

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.

Oncotarget

Cheng L,Jin Y,Liu M,Ruan M,Chen L

Tue Mar 21 00:00:00 UTC 2017

Dominant negative effect of mutated thyroid stimulating hormone receptor (P556L) causes hypothyroidism in C.RF-Tshr(hyt/wild) mice.

PloS one

Endo T,Kobayashi T

Wed May 15 00:00:00 UTC 2013

Dominant negative effect of mutated thyroid stimulating hormone receptor (P556L) causes hypothyroidism in C.RF-Tshr(hyt/wild) mice.

PloS one

Endo T,Kobayashi T

Wed May 15 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R

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Gene Aliases: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; pet; TSHR; TSHRA

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UniProt ID: (Human) P16473, (Mouse) P47750, (Rat) P21463

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Entrez Gene ID: (Human) 7253, (Mouse) 22095, (Rat) 25360

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Function(s)

thyroid-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity signal transducer activity G-protein coupled receptor activity protein-hormone receptor activity

Process(es)

signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cell proliferation adult locomotory behavior hormone-mediated signaling pathway B cell differentiation thyroid-stimulating hormone signaling pathway regulation of locomotion positive regulation of multicellular organism growth inner ear receptor cell development inner ear receptor stereocilium organization dopaminergic neuron differentiation cochlea morphogenesis G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cell-cell signaling nervous system development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TSHR Polyclonal Antibody

TSHR Antibody (14450-1-AP) in WB

Product Details

14450-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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