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A novel putative serine/threonine kinase substrate gene (TSKS, for testis-specific kinase substrate) is likely the human homolog of the mouse testis-specific serine kinase substrate gene. TSKS exhibits high levels of expression exclusively in human testicular tissue. The expression of TSKS is downregulated in cancerous testicular tissue, in comparison to adjacent normal tissue. These observations suggest a role of TSKS in testicular physiology, most probably in the process of spermatogenesis or spermiogenesis.
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Protein Aliases: clone 4; protein phosphatase 1, regulatory subunit 161; serine/threonine kinase 22 substrate 1; STK22 substrate 1; testis specific serine/threonine kinase substrate; Testis-specific kinase substrate; Testis-specific serine kinase substrate; testis-specific serine/threonine kinase substrate 1
Gene Aliases: PPP1R161; STK22S1; TSKS; TSKS1; TSSKS; Tssks1
UniProt ID: (Human) Q9UJT2, (Rat) P60531, (Mouse) O54887
Entrez Gene ID: (Human) 60385, (Rat) 292890, (Mouse) 22116
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