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Product Details
H00010077-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2B4
Immunogen
TSPAN32 (NP_005696, 194 a.a. approximately 290 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: RCGCSLDRKG KYTLTPRACG RQPQEPSLLR CSQGGPTHCL HSEAVAIGPR GCSGSLRWLQ ESDAAPLPLS CHLAAHRALQ GRSRGGLSGC PERGLSD
Target Information
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ17158; FLJ97586; MGC22455; pan-hematopoietic expression protein; Protein Phemx; tetraspanin; Tetraspanin-32; Tspan-32; tumor-suppressing STF cDNA 6; tumor-suppressing subchromosomal transferable fragment cDNA 6; tumor-suppressing subtransferable candidate 6
Gene Aliases: ART1; PHEMX; PHMX; TSPAN32; TSSC6
UniProt ID: (Human) Q96QS1
Entrez Gene ID: (Human) 10077
cytoskeleton organization
cell surface receptor signaling pathway
integrin-mediated signaling pathway
cell-cell signaling
negative regulation of cell proliferation
negative regulation of myeloid dendritic cell activation
defense response to protozoan
regulation of defense response to virus
platelet aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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