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Proteintech
TSPO Monoclonal Antibody (1D1F12)
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Product Details
68137-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
1D1F12
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Caprylic acid precipitation, Ammonium sulfate precipitation
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFATTL NYCVWRDNHG WHGGRRLPE
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; isoquinoline-binding protein; Mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein; translocator protein (18kDa)
Gene Aliases: BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; TSPO; Tspo1
UniProt ID: (Human) P30536, (Rat) P16257, (Mouse) P50637
Entrez Gene ID: (Human) 706, (Rat) 24230, (Mouse) 12257
steroid biosynthetic process
ion transport
chloride transport
lipid transport
chemical synaptic transmission
aging
glial cell migration
response to manganese ion
response to vitamin B1
positive regulation of necrotic cell death
peripheral nervous system axon regeneration
adrenal gland development
response to progesterone
negative regulation of tumor necrosis factor production
response to testosterone
response to drug
positive regulation of apoptotic process
negative regulation of nitric oxide biosynthetic process
response to pain
behavioral response to pain
response to axon injury
regulation of steroid biosynthetic process
positive regulation of mitochondrial depolarization
positive regulation of calcium ion transport
contact inhibition
positive regulation of glial cell proliferation
negative regulation of glial cell proliferation
cellular response to lipopolysaccharide
cellular response to zinc ion
cellular hypotonic response
positive regulation of reactive oxygen species metabolic process
transport
signal transduction
protein targeting to mitochondrion
heme biosynthetic process
anion transport
apoptotic process
steroid metabolic process
cell proliferation
negative regulation of protein ubiquitination
regulation of cholesterol transport
maintenance of protein location in mitochondrion
negative regulation of mitophagy
negative regulation of ATP metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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