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Product Details
PA5-99842
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TSSK6(Accession Q9BXA6), corresponding to amino acid residues A122-C172.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2818775
Product Specific Information
Antibody detects endogenous levels of total TSSK6.
Target Information
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 72; CT72; serine/threonine protein kinase SSTK; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase; testis secretory sperm-binding protein Li 205a; testis-specific kinase 6; testis-specific serine kinase 6; Testis-specific serine/threonine-protein kinase 6; TSK-6; TSSK-6; TSSK6
Gene Aliases: CT72; FKSG82; RGD1559764; SSTK; TSSK4; TSSK6
UniProt ID: (Human) Q9BXA6, (Mouse) Q925K9
Entrez Gene ID: (Human) 83983, (Mouse) 83984, (Rat) 290670
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