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Immunogen sequence: MAGAPTVSLP ELRSLLASGR ARLFDVRSRE EAAAGTIPGA LNIPVSELES ALQMEPAAFQ ALYSAEKPKL EDEHLVFFCQ MGKRGLQATQ LARSLGYTGY G
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 81%.
Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). [UniProt]
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Protein Aliases: putative thiosulfate sulfurtransferase KAT; thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; thiosulfate sulfurtransferase KAT, putative; Thiosulfate:glutathione sulfurtransferase; TST
Gene Aliases: KAT; TSTD1
UniProt ID: (Human) Q8NFU3
Entrez Gene ID: (Human) 100131187
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