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Invitrogen
TTBK2 Polyclonal Antibody
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Product Details
PA5-100923
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TTBK2(Accession Q6IQ55), corresponding to amino acid residues S1109-S1159.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850416
Product Specific Information
Antibody detects endogenous levels of total TTBK2.
Target Information
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein bartleby; Tau-tubulin kinase 2
Gene Aliases: 2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; SCA11; TTBK; Ttbk1; TTBK2; TTK
UniProt ID: (Human) Q6IQ55, (Mouse) Q3UVR3
Entrez Gene ID: (Human) 146057, (Mouse) 140810
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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