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Product Details
PA5-54942
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TTC3. Recombinant protein control fragment (Product #RP-91795).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2649059
Product Specific Information
Immunogen sequence: DCPHVDDCVF AAEFMSNDYV RVTQLYCDGV GVQYKDYIQS ERNLEFDICS IWCSKPISVL QDYCDAIKIN IFWPLLFQHQ NSSVISRLHP CVDANNSRAS EINLKKLQHL ELMEDIVDLA KKVANDS
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 77%.
Target Information
E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase TTC3; Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; Tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D
Gene Aliases: DCRR1; RNF105; TPRD; TPRDIII; TTC3
UniProt ID: (Human) P53804
Entrez Gene ID: (Human) 7267
Performance Guarantee
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