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Proteintech
TTC30A Polyclonal Antibody
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Product Details
25352-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TTC30A Fusion Protein Ag18361 (1-342 aa encoded by BC042848)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGLSGAQI PDGEFTALVY RLIRDARYAE AVQLLGRELQ RSPRSRAGLS LLGYCYYRLQ EFALAAECYE QLGQLHPELE QYRLYQAQAL YKACLYPEAT RVAFLLLDNP AYHSRVLRLQ AAIKYSEGDL PGSRSLVEQL LSGEGGEESG GDNETDGQVN LGCLLYKEGQ YEAACSKFSA TLQASGYQPD LSYNLALAYY SSRQYASALK HIAEIIERGI RQHPELGVGM TTEGFDVRSV GNTLVLHQTA LVEAFNLKAA IEYQLRNYEV AQETLTDMPP RAEEELDPVT LHNQALMNMD ARPTEGFEKL QFLLQQNPFP PETFGNLLLL YCKYEYFDLA ADV (1-342 aa encoded by BC042848)
Target Information
The TTC30A gene encodes for the Tetratricopeptide Repeat Domain 30A, which is part of the intraflagellar transport (IFT) complex B, critical for ciliary function. TTC30A and its paralog TTC30B are involved in the stability and functioning of the IFT complex. These proteins play a redundant role in maintaining cilia integrity, necessary for proper cellular signaling and homeostasis. Disruption of TTC30A, through CRISPR/Cas9 gene editing, has shown to impair ciliogenesis, leading to developmental defects such as limb malformations and polycystic kidney disease due to altered tubulin acetylation and ciliary transport. This highlights the importance of TTC30A in cellular and developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Intraflagellar transport protein 70A; tetratricopeptide repeat domain 30B; Tetratricopeptide repeat protein 30A; TPR repeat protein 30A
Gene Aliases: IFT70A; TTC30A
UniProt ID: (Human) Q86WT1
Entrez Gene ID: (Human) 92104, (Rat) 100362431
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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