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Product Details
PA5-21835
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TTC30A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11151836
Product Specific Information
Recommended positive controls: 293T, A431, HepG2, Molt-4.
Predicted reactivity: Rat (90%), Xenopus laevis (88%), Chicken (85%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The TTC30A gene encodes for the Tetratricopeptide Repeat Domain 30A, which is part of the intraflagellar transport (IFT) complex B, critical for ciliary function. TTC30A and its paralog TTC30B are involved in the stability and functioning of the IFT complex. These proteins play a redundant role in maintaining cilia integrity, necessary for proper cellular signaling and homeostasis. Disruption of TTC30A, through CRISPR/Cas9 gene editing, has shown to impair ciliogenesis, leading to developmental defects such as limb malformations and polycystic kidney disease due to altered tubulin acetylation and ciliary transport. This highlights the importance of TTC30A in cellular and developmental processes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Intraflagellar transport protein 70A; Tetratricopeptide repeat protein 30A; TPR repeat protein 30A
Gene Aliases: IFT70A; TTC30A
UniProt ID: (Human) Q86WT1
Entrez Gene ID: (Human) 92104
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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