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Product Details
PA5-116969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 536-789 of human TTK (NP_0033092)
Conjugate
Form
Liquid
Concentration
1.83 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901599
Product Specific Information
Positive Samples: HeLa
Immunogen sequence: SSKVFQVLNE KKQIYAIKYV NLEEADNQTL DSYRNEIAYL NKLQQHSDKI IRLYDYEITD QYIYMVMECG NIDLNSWLKK KKSIDPWERK SYWKNMLEAV HTIHQHGIVH SDLKPANFLI VDGMLKLIDF GIANQMQPDT TSVVKDSQVG TVNYMPPEAI KDMSSSRENG KSKSKISPKS DVWSLGCILY YMTYGKTPFQ QIINQISKLH AIIDPNHEIE FPDIPEKDLQ DVLKCCLKRD PKQRISIPEL LAHP
Target Information
TTK is a serine/threonine kinase closely related to SPK1, PIM 1 and CDC2 serine/threonine kinases. TTK is a dual-specificity kinase, which can also phosphorylate tyrosine. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. TTK encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cancer/testis antigen 96; Dual specificity protein kinase TTK; monopolar spindle 1 kinase; monopolar spindle 1-like 1; OTTHUMP00000016778; OTTHUMP00000220743; phosphotyrosine picked threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT
Gene Aliases: AL022661; CT96; ESK; Esk1; MPH1; MPS1; MPS1L1; PYT; TTK
UniProt ID: (Human) P33981
Entrez Gene ID: (Human) 7272, (Rat) 315852, (Mouse) 22137
protein phosphorylation
mitotic cell cycle checkpoint
chromosome separation
phosphorylation
spindle organization
mitotic spindle organization
mitotic spindle assembly checkpoint
positive regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-tyrosine phosphorylation
Performance Guarantee
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