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Product Details
26014-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TTLL10 Fusion Protein Ag23258 (1-245 aa encoded by BC126152)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGSSQEEGL RCQPSQPDHD ADGHCGPDLE GAERASATPG PPGLLNSHRP ADSDDTNAAG PSAALLEGLL LGGGKPSPHS TRPGPFFYIG GSNGATIISS YCKSKGWQRI HDSRRDDYTL KWCEVKSRDS YGSFREGEQL LYQLPNNKLL TTKIGLLSTL RGRARAMSKA SKVPGGVQAR LEKDAAAPAL EDLPWTSPGY LRPQRVLRME EFFPETYRLD LKHEREAFFT LFDETQIWIC KPTASN (1-245 aa encoded by B C126152)
Target Information
The TTLL10 gene encodes a protein that functions as a polyglycylase, playing an important role in the modification of nucleosome assembly protein 1 (NAP1) both in vivo and in vitro. This enzymatic activity is dependent on the presence of ATP and is abolished in mutant forms where the glutamate in the active site is replaced by valine. TTLL10 specifically incorporates glycine into recombinant NAP1 at Glu residues 359 and 360. This modification process likely has implications for protein interactions and cellular processes involving NAP1. Additionally, TTLL10 can perform tubulin glycylation when co-expressed with TTLL8, suggesting a complex interplay between these enzymes in cellular microtubule dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inactive polyglycylase TTLL10; Protein polyglycylase TTLL10; tubulin tyrosine ligase-like family member 10; tubulin tyrosine ligase-like family, member 10; tubulin tyrosine ligase-like family, member 5; Tubulin--tyrosine ligase-like protein 10
Gene Aliases: 4833412E22Rik; 4930595O22Rik; AU022799; BC042775; TTLL10; TTLL5
UniProt ID: (Human) Q6ZVT0, (Mouse) A4Q9F3, (Rat) Q5XI57
Entrez Gene ID: (Human) 254173, (Mouse) 330010, (Rat) 298692
protein binding
ATP binding
protein-glycine ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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