Proteintech

TTRAP Polyclonal Antibody

FIGURE: 1 / 2

TTRAP Antibody (12203-1-AP) in WB

Human spleen tissue were subjected to SDS PAGE followed by western blot with 12203-1-AP (TTRAP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

TTRAP Antibody in Immunoprecipitation (IP)

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Product Details

12203-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TTRAP Fusion Protein Ag2846 (1-362 aa encoded by BC017553)

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MELGSCLEG GREAAEEEGE PEVKKRRLLC VEFASVASCD AAVAQCFLAE NDWEMERALN SYFEPPVEES ALERRPETIS EPKTYVDLTN EETTDSTTSK ISPSEDTQQE NGSMFSLITW NIDGLDLNNL SERARGVCSY LALYSPDVIF LQEVIPPYYS YLKKRSSNYE IITGHEEGYF TAIMLKKSRV KLKSQEIIPF PSTKMMRNLL CVHVNVSGNE LCLMTSHLES TRGHAAERMN QLKMVLKKMQ EAPESATVIF AGDTNLRDRE VTRCGGLPNN IVDVWEFLGK PKHCQYTWDT QMNSNLGITA ACKLRFDRIF FRAAAEEGHI IPRSLDLLGL EKLDCGRFPS DHWGLLCNLD IIL (1-362 aa encoded by BC017553)

Target Information

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer.

International journal of molecular sciences

Flörkemeier I,Hillmann JS,Weimer JP,Hildebrandt J,Hedemann N,Rogmans C,Dempfle A,Arnold N,Clement B,Bauerschlag DO

Sat Sep 10 00:00:00 UTC 2022

NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.

Cell death and differentiation

Zhang B,Tang Z,Li L,Lu LY

Wed Jul 01 00:00:00 UTC 2020

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Nucleic acids research

Schellenberg MJ,Perera L,Strom CN,Waters CA,Monian B,Appel CD,Vilas CK,Williams JG,Ramsden DA,Williams RS

Thu May 05 00:00:00 UTC 2016

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Nucleic acids research

Schellenberg MJ,Perera L,Strom CN,Waters CA,Monian B,Appel CD,Vilas CK,Williams JG,Ramsden DA,Williams RS

Thu May 05 00:00:00 UTC 2016

Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.

Analytical biochemistry

Thomson G,Watson A,Caldecott K,Denneny O,Depledge P,Hamilton N,Hopkins G,Jordan A,Morrow C,Raoof A,Waddell I,Ogilvie D

Wed May 15 00:00:00 UTC 2013

Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.

Analytical biochemistry

Thomson G,Watson A,Caldecott K,Denneny O,Depledge P,Hamilton N,Hopkins G,Jordan A,Morrow C,Raoof A,Waddell I,Ogilvie D

Wed May 15 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; EAPII; ETS1-associated protein 2; ETS1-associated protein II; MGC111021; MGC9099; RP1-30M3.3; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; Tyr-DNA phosphodiesterase 2; Tyrosyl-DNA phosphodiesterase 2; Tyrosyl-RNA phosphodiesterase; VPg unlinkase

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Gene Aliases: AD-022; AD022; D13Ertd656e; dJ30M3.3; EAP2; EAPII; hTDP2; TDP2; TTRAP

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UniProt ID: (Human) O95551, (Mouse) Q9JJX7, (Rat) Q3T1H5

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Entrez Gene ID: (Human) 51567, (Mouse) 56196, (Rat) 498749

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Function(s)

Process(es)

DNA repair double-strand break repair cellular response to DNA damage stimulus nucleic acid phosphodiester bond hydrolysis cell surface receptor signaling pathway negative regulation of nucleic acid-templated transcription

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TTRAP Polyclonal Antibody

TTRAP Antibody (12203-1-AP) in WB

Product Details

12203-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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