Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
TWIST2 Monoclonal Antibody (1B12D11)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
66544-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B12D11
Immunogen
TWIST2 Fusion Protein Ag2348 (1-160 aa encoded by BC033168)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEEGSSSPV SPVDSLGTSE EELERQPKRF GRKRRYSKKS SEDGSPTPGK RGKKGSPSAQ SFEELQSQRI LANVRERQRT QSLNEAFAAL RKIIPTLPSD KLSKIQTLKL AARYIDFLYQ VLQSDEMDNK MTSCSYVAHE RLSYAFSVWR MEGAWSMSAS H (1-160 aa encoded by BC033168)
Target Information
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHa39; Class A basic helix-loop-helix protein 39; dermis expressed 1; Dermis-expressed protein 1; Dermo-1; dermo-1 protein; twist basic helix-loop-helix transcription factor 2; twist homolog 2; twist-related bHLH protein Dermo1; Twist-related protein 2
Gene Aliases: AMS; BBRSAY; BHLHA39; DERMO1; FFDD3; SETLSS; TWIST2
UniProt ID: (Human) Q8WVJ9, (Mouse) Q9D030, (Rat) P97831
Entrez Gene ID: (Human) 117581, (Mouse) 13345, (Rat) 59327
transcription, DNA-templated
multicellular organism development
cell differentiation
negative regulation of apoptotic process
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
positive regulation of keratinocyte proliferation
negative regulation of tumor necrosis factor production
negative regulation of DNA binding
negative regulation of molecular function
negative regulation of myeloid cell differentiation
embryonic cranial skeleton morphogenesis
face morphogenesis
cornea development in camera-type eye
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support