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Product Details
18981-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein-tyrosine kinase 4; PTK4 protein tyrosine kinase 4; Resting lymphocyte kinase; tyrosine kinase; Tyrosine-protein kinase TXK
Gene Aliases: BTKL; PSCTK5; PTK4; RLK; TKL; TXK
UniProt ID: (Human) P42681
Entrez Gene ID: (Human) 7294
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
cytokine production
adaptive immune response
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
activation of phospholipase C activity
integrin-mediated signaling pathway
regulation of platelet activation
cell differentiation
positive regulation of interferon-gamma production
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
tissue regeneration
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
T cell receptor signaling pathway
positive regulation of interferon-gamma-mediated signaling pathway
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