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Product Details
CL594-66475
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1F3C1
Immunogen
Recombinant Protein
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADF; ATL-derived factor; DKFZp686B1993; MGC61975; RP11-427L11.1; SASP; Surface-associated sulphydryl protein; testicular tissue protein Li 199; Thioredoxin; thioredoxin delta 3; Trx; TXN delta 3
Gene Aliases: TRDX; TRX; TRX1; TXN
UniProt ID: (Human) P10599
Entrez Gene ID: (Human) 7295
sulfate assimilation
negative regulation of transcription from RNA polymerase II promoter
response to reactive oxygen species
transcription, DNA-templated
protein folding
glycerol ether metabolic process
movement of cell or subcellular component
signal transduction
cell-cell signaling
cell proliferation
response to radiation
nucleobase-containing small molecule interconversion
protein repair
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
regulation of protein import into nucleus, translocation
positive regulation of DNA binding
cell redox homeostasis
negative regulation of protein export from nucleus
positive regulation of protein kinase B signaling
oxidation-reduction process
negative regulation of hydrogen peroxide-induced cell death
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