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Invitrogen
TXNIP Polyclonal Antibody
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FIGURE: 1 / 2
TXNIP Antibody (PA5-23485) in WB
Western blot was performed using Anti-TXNIP Polyclonal Antibody (Product # PA5-23485) and a 43 kDa band corresponding to TXNIP was observed across all cell lines and tissue and increased upon treatment with H2O2 and IGF1 in HEK-293 while decreased upon H2O2 treatment in HeLa. Whole cell extracts (30 µg lysate) of HEK-293 (Lane 1), HEK-293 treated with H2O2 (300mM for 2hr) (Lane 2), HEK-293 treated with IGF1 (50 ng/mL for 2hr) (Lane 3), HeLa (Lane 4), HeLa treated with H2O2 (300mM for 2hr) (Lane 5) and Mouse brain (Lane 6) were electrophore... View More
Product Details
PA5-23485
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 100-150 of human TxNIP
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540985
Target Information
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hyperlipidemia 1; thioredoxin binding protein 2; thioredoxin binding protein-2; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; Vitamin D3 up-regulated protein 1
Gene Aliases: 1200008J08Rik; AA682105; ARRDC6; EST01027; HHCPA78; Hyplip1; Tbp-2; THIF; TXNIP; VDUP1
UniProt ID: (Human) Q9H3M7, (Rat) Q5M7W1, (Mouse) Q8BG60
Entrez Gene ID: (Human) 10628, (Rat) 117514, (Mouse) 56338
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein import into nucleus
cell cycle
response to mechanical stimulus
response to glucose
keratinocyte differentiation
response to estradiol
response to progesterone
regulation of cell proliferation
response to drug
response to hydrogen peroxide
positive regulation of apoptotic process
negative regulation of catalytic activity
platelet-derived growth factor receptor signaling pathway
response to calcium ion
negative regulation of cell division
cellular response to tumor cell
response to oxidative stress
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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