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Invitrogen
Tet Polyclonal Antibody
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Tet Antibody (PA5-144574) in WB
Western blot analysis of Tet in recombinant protein using a dilution of 1:1,000. Samples were incubated with Tet polyclonal antibody (Product # PA5-144574). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa.
Product Details
PA5-144574
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Fruit fly Tet protein (2494-2767aa)
Conjugate
Form
Liquid
Concentration
2.8 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3091668
Target Information
Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936838, PubMed:30078725). N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression (PubMed:25936838). Promotes differentiation of early germ cells in ovary (PubMed:25936838). Contributes to neuronal morphology, development, and function in the brain (PubMed:30078725). By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation (PubMed:30078725). Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:25936838).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG43444-PA; CG43444-PB; CG43444-PC; CG43444-PD; CG43444-PE; CG43444-PF; DMAD; DNA 6mA demethylase; DNA N6-methyl adenine demethylase; Methylcytosine dioxygenase TET; Ten-Eleven translocation (TET) family protein; TET family protein; Tet-PA; Tet-PB; Tet-PC; Tet-PD; Tet-PE; Tet-PF
Gene Aliases: CG2083; CG43444; CG9973; DMAD; Dmel\CG43444; Dmel_CG43444; dTet; Idax; Tet
UniProt ID: (Fruit fly) M9NEY8
Entrez Gene ID: (Fruit fly) 38347
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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