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Alomone Labs, LTD
Thromboxane A2 Receptor (extracellular) Polyclonal Antibody, FITC
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FIGURE: 1 / 2
Thromboxane A2 Receptor (extracellular) Antibody (APR-095-F-50UL) in Flow
Cell surface detection of Thromboxane A2 Receptor by direct flow cytometry in live intact human MEG-01 megakaryoblast leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-Thromboxane A2 Receptor (extracellular)-FITC Antibody (#APR-095-F), (5 µg).
Product Details
APR-095-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RPTNITLEERRLIAS, corresponding to amino acid residues 13-27 of human TBXA2R, Extracellular, N-terminus
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The thromboxane A2 receptor (TBXA2R) is a member of the Prostanoid Receptor subfamily. TBXA2R performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 has been implicated in myocardial infarct, stroke, and asthma. Additionally, thromboxane-prostanoid receptors have been implicated in the pathogenesis of cardiovascular diseases. Changes in TBXA2R function have also been linked to a hereditary bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Prostanoid TP receptor; Thromboxane A2 receptor; thromboxane prostanoid; Thromboxane receptor; TXA2 receptor; TXA2-R; TXR2
Gene Aliases: BDPLT13; TBXA2R; TP; TXA2-R
UniProt ID: (Human) P21731, (Mouse) P30987, (Rat) P34978
Entrez Gene ID: (Human) 6915, (Mouse) 21390, (Rat) 24816
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of vasoconstriction
second-messenger-mediated signaling
response to lipopolysaccharide
positive regulation of angiogenesis
positive regulation of blood pressure
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
thromboxane A2 signaling pathway
response to drug
positive regulation of GTPase activity
water homeostasis
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