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Invitrogen
Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (HL1237)
FIGURE: 1 / 3
Thymidylate Synthase Antibody (MA5-46969) in IHC (P)
Immunohistochemistry analysis of Thymidylate Synthase in paraffin-embedded mouse thymus gland. Samples were incubated in Thymidylate Synthase Monoclonal antibody (Product # MA5-46969). Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
MA5-46969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cat,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1237
Immunogen
Recombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938041
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC88736; Thymidylate synthase; TS; TSase; tysy
Gene Aliases: HST422; OK/SW-cl.29; TMS; TS; TYMS
UniProt ID: (Human) P04818, (Mouse) P07607
Entrez Gene ID: (Human) 7298, (Dog) 607417, (Mouse) 22171
dTMP biosynthetic process
nucleotide biosynthetic process
methylation
dUMP metabolic process
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
nucleobase-containing compound metabolic process
dTTP biosynthetic process
aging
circadian rhythm
cell proliferation
deoxyribonucleoside monophosphate biosynthetic process
response to toxic substance
cell growth
immortalization of host cell by virus
uracil metabolic process
organ regeneration
response to progesterone
response to vitamin A
response to cytokine
tetrahydrofolate interconversion
response to drug
response to ethanol
pyrimidine nucleoside biosynthetic process
response to organophosphorus
developmental growth
cartilage development
response to glucocorticoid
response to folic acid
intestinal epithelial cell maturation
DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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