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Product Details
MA5-15666
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B5
Immunogen
Purified recombinant fragment of human CRTC1 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10980185
Product Specific Information
MA5-15666 targets CRTC1 in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15666 immunogen is purified recombinant fragment of human CRTC1 expressed in E. Coli.
.
MA5-15666 detects CRTC1 which has a predicted molecular weight of approximately 67kDa.
Target Information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CREB-regulated transcription coactivator 1; CRTC1; FLJ14027; MECT 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1
Gene Aliases: CRTC1; KIAA0616; MECT1; TORC-1; TORC1; WAMTP1
UniProt ID: (Human) Q6UUV9
Entrez Gene ID: (Human) 23373
transcription, DNA-templated
memory
viral process
positive regulation of CREB transcription factor activity
entrainment of circadian clock by photoperiod
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
protein homotetramerization
membrane hyperpolarization
positive regulation of dendrite development
positive regulation of long-term synaptic potentiation
Performance Guarantee
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