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Invitrogen
Transferrin Receptor Monoclonal Antibody (MRC OX-26)
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FIGURE: 1 / 7
Transferrin Receptor Antibody (MA1-90784) in WB
Western blot was performed using Anti-Transferrin Receptor Monoclonal Antibody (MRC OX-26)(Product # MA1-90784) and a 84kDa band corresponding to Transferrin Receptor was observed across cell line tested. Whole cell extracts (30 µg lysate) of HeLa (Lane 1), Hep G2 (Lane 2), U-87 MG (Lane 3) and MCF-7 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved prote... View More
Product Details
MA1-90784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MRC OX-26
Immunogen
PHA activated rat lymphocytes.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
IgG fraction
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2201365
Product Specific Information
MA1-90784 detects CD71 from rat samples.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD71; CD71; mammary tumor virus receptor 1; tfR; tfR1; TR; Transferrin receptor protein 1
Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; p90; TFR; TFR1; Tfrc; TR; Trfr
UniProt ID: (Rat) Q99376, (Mouse) Q62351
Entrez Gene ID: (Rat) 64678, (Mouse) 22042
regulation of cell growth
response to hypoxia
cellular iron ion homeostasis
receptor-mediated endocytosis
acute-phase response
aging
response to nutrient
response to organic substance
response to inorganic substance
response to iron ion
response to manganese ion
osteoclast differentiation
response to retinoic acid
transferrin transport
cellular response to drug
regulation of cell proliferation
positive regulation of bone resorption
response to copper ion
iron ion import
endocytosis
iron ion transmembrane transport
protein transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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