Proteintech

Transketolase Polyclonal Antibody

Transketolase Antibody in Immunocytochemistry (ICC/IF)

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Transketolase Antibody (11039-1-AP) in ICC/IF

Immunofluorescent analysis of BxPC-3 cells using 11039-1-AP (Transketolase antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Transketolase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Transketolase Antibody in Western Blot (WB)

Product Image Gallery

Product Details

11039-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 17 publications 17 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Transketolase Fusion Protein Ag1519 (274-623 aa encoded by BC009970)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IYSQIQSKK KILATPPQED APSVDIANIR MPSLPSYKVG DKIATRKAYG QALAKLGHAS DRIIALDGDT KNSTFSEIFK KEHPDRFIEC YIAEQNMVSI AVGCATRNRT VPFCSTFAAF FTRAFDQIRM AAISESNINL CGSHCGVSIG EDGPSQMALE DLAMFRSVPT STVFYPSDGV ATEKAVELAA NTKGICFIRT SRPENAIIYN NNEDFQVGQA KVVLKSKDDQ VTVIGAGVTL HEALAAAELL KKEKINIRVL DPFTIKPLDR KLILDSARAT KGRILTVEDH YYEGGIGEAV SSAVVGEPGI TVTHLAVNRV PRSGKPAELL KMFGIDRDAI AQAVRGLITK A (274-623 aa encoded by BC009970)

Target Information

Transketolase encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics.

Experimental cell research

Ochi N,Takeyama M,Miyake N,Fuchigami M,Yamane H,Fukazawa T,Nagasaki Y,Kawahara T,Nakanishi H,Takigawa N

Wed Mar 01 00:00:00 UTC 2023

M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.

International journal of biological sciences

Zhong C,Long Z,Yang T,Wang S,Zhong W,Hu F,Teoh JY,Lu J,Mao X

Tue Apr 18 00:00:00 UTC 2023

Erythritol synthesis is elevated in response to oxidative stress and regulated by the non-oxidative pentose phosphate pathway in A549 cells.

Frontiers in nutrition

Ortiz SR,Heinz A,Hiller K,Field MS

Tue Oct 25 00:00:00 UTC 2022

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer.

Frontiers in medicine

Zhang L,Huang Z,Cai Q,Zhao C,Xiao Y,Quan X,Tang C,Gao J

Tue Mar 15 00:00:00 UTC 2022

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer.

Frontiers in medicine

Zhang L,Huang Z,Cai Q,Zhao C,Xiao Y,Quan X,Tang C,Gao J

Tue Mar 15 00:00:00 UTC 2022

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer.

Frontiers in medicine

Zhang L,Huang Z,Cai Q,Zhao C,Xiao Y,Quan X,Tang C,Gao J

Tue Mar 15 00:00:00 UTC 2022

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer.

Frontiers in medicine

Zhang L,Huang Z,Cai Q,Zhao C,Xiao Y,Quan X,Tang C,Gao J

Tue Mar 15 00:00:00 UTC 2022

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.

Nature communications

Yang R,Yang C,Ma L,Zhao Y,Guo Z,Niu J,Chu Q,Ma Y,Li B

Thu Nov 17 00:00:00 UTC 2022

Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes.

Journal of hazardous materials

Zhu Y,Zhang Y,Li Y,Guo C,Fan Z,Li Y,Yang M,Zhou X,Sun Z,Wang J

Fri Jul 15 00:00:00 UTC 2022

Glycolysis addiction compensating for a defective pentose phosphate pathway confers gemcitabine sensitivity in SETD2-deficient pancreatic cancer.

Biochemical and biophysical research communications

Shen X,Chen Y,Liu M,Shi J,Tang Y,Yang X,Xu D,Yao H,Lu P,Sun Y,Xue J,Niu N

Sat Jul 30 00:00:00 UTC 2022

Glycolysis addiction compensating for a defective pentose phosphate pathway confers gemcitabine sensitivity in SETD2-deficient pancreatic cancer.

Biochemical and biophysical research communications

Shen X,Chen Y,Liu M,Shi J,Tang Y,Yang X,Xu D,Yao H,Lu P,Sun Y,Xue J,Niu N

Sat Jul 30 00:00:00 UTC 2022

A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets.

Molecular psychiatry

Pandya NJ,Meier S,Tyanova S,Terrigno M,Wang C,Punt AM,Mientjes EJ,Vautheny A,Distel B,Kremer T,Elgersma Y,Jagasia R

Sun May 01 00:00:00 UTC 2022

TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer.

Bioengineered

Sun J,Chen X,Ji X,Meng S,Wang W,Wang P,Bai J,Li Z,Chen Y

Tue Mar 01 00:00:00 UTC 2022

TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer.

Bioengineered

Sun J,Chen X,Ji X,Meng S,Wang W,Wang P,Bai J,Li Z,Chen Y

Tue Mar 01 00:00:00 UTC 2022

Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation.

Cell death & disease

Li M,Zhao X,Yong H,Xu J,Qu P,Qiao S,Hou P,Li Z,Chu S,Zheng J,Bai J

Wed Feb 02 00:00:00 UTC 2022

Mitochondrial NADP⁺ is essential for proline biosynthesis during cell growth.

Nature metabolism

Tran DH,Kesavan R,Rion H,Soflaee MH,Solmonson A,Bezwada D,Vu HS,Cai F,Phillips JA,DeBerardinis RJ,Hoxhaj G

Thu Apr 01 00:00:00 UTC 2021

Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis.

Cancer letters

Chen X,Li Z,Yong H,Wang W,Wang D,Chu S,Li M,Hou P,Zheng J,Bai J

Mon Jun 28 00:00:00 UTC 2021

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Nature communications

Wang XH,Xu S,Zhou XY,Zhao R,Lin Y,Cao J,Zang WD,Tao H,Xu W,Li MQ,Zhao SM,Jin LP,Zhao JY

Tue Jun 08 00:00:00 UTC 2021

Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.

Journal of experimental & clinical cancer research : CR

Qin Z,Xiang C,Zhong F,Liu Y,Dong Q,Li K,Shi W,Ding C,Qin L,He F

Thu Apr 11 00:00:00 UTC 2019

Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.

Journal of experimental & clinical cancer research : CR

Qin Z,Xiang C,Zhong F,Liu Y,Dong Q,Li K,Shi W,Ding C,Qin L,He F

Thu Apr 11 00:00:00 UTC 2019

Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.

Journal of experimental & clinical cancer research : CR

Qin Z,Xiang C,Zhong F,Liu Y,Dong Q,Li K,Shi W,Ding C,Qin L,He F

Thu Apr 11 00:00:00 UTC 2019

Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.

Clinical & experimental metastasis

Ricciardelli C,Lokman NA,Cheruvu S,Tan IA,Ween MP,Pyragius CE,Ruszkiewicz A,Hoffmann P,Oehler MK

Mon Jun 01 00:00:00 UTC 2015

Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.

Clinical & experimental metastasis

Ricciardelli C,Lokman NA,Cheruvu S,Tan IA,Ween MP,Pyragius CE,Ruszkiewicz A,Hoffmann P,Oehler MK

Mon Jun 01 00:00:00 UTC 2015

Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.

Clinical & experimental metastasis

Ricciardelli C,Lokman NA,Cheruvu S,Tan IA,Ween MP,Pyragius CE,Ruszkiewicz A,Hoffmann P,Oehler MK

Mon Jun 01 00:00:00 UTC 2015

Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.

Clinical & experimental metastasis

Ricciardelli C,Lokman NA,Cheruvu S,Tan IA,Ween MP,Pyragius CE,Ruszkiewicz A,Hoffmann P,Oehler MK

Mon Jun 01 00:00:00 UTC 2015

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

Proceedings of the National Academy of Sciences of the United States of America

Chen L,Shu Y,Liang X,Chen EC,Yee SW,Zur AA,Li S,Xu L,Keshari KR,Lin MJ,Chien HC,Zhang Y,Morrissey KM,Liu J,Ostrem J,Younger NS,Kurhanewicz J,Shokat KM,Ashrafi K,Giacomini KM

Tue Jul 08 00:00:00 UTC 2014

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

Proceedings of the National Academy of Sciences of the United States of America

Chen L,Shu Y,Liang X,Chen EC,Yee SW,Zur AA,Li S,Xu L,Keshari KR,Lin MJ,Chien HC,Zhang Y,Morrissey KM,Liu J,Ostrem J,Younger NS,Kurhanewicz J,Shokat KM,Ashrafi K,Giacomini KM

Tue Jul 08 00:00:00 UTC 2014

Malignant pleural effusion cells show aberrant glucose metabolism gene expression.

The European respiratory journal

Lin CC,Chen LC,Tseng VS,Yan JJ,Lai WW,Su WP,Lin CH,Huang CY,Su WC

Wed Jun 01 00:00:00 UTC 2011

Malignant pleural effusion cells show aberrant glucose metabolism gene expression.

The European respiratory journal

Lin CC,Chen LC,Tseng VS,Yan JJ,Lai WW,Su WP,Lin CH,Huang CY,Su WC

Wed Jun 01 00:00:00 UTC 2011

Malignant pleural effusion cells show aberrant glucose metabolism gene expression.

The European respiratory journal

Lin CC,Chen LC,Tseng VS,Yan JJ,Lai WW,Su WP,Lin CH,Huang CY,Su WC

Wed Jun 01 00:00:00 UTC 2011

Malignant pleural effusion cells show aberrant glucose metabolism gene expression.

The European respiratory journal

Lin CC,Chen LC,Tseng VS,Yan JJ,Lai WW,Su WP,Lin CH,Huang CY,Su WC

Wed Jun 01 00:00:00 UTC 2011

Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts.

Proteomics

Xu BJ,Yan W,Jovanovic B,An AQ,Cheng N,Aakre ME,Yi Y,Eng J,Link AJ,Moses HL

Thu Jul 01 00:00:00 UTC 2010

Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts.

Proteomics

Xu BJ,Yan W,Jovanovic B,An AQ,Cheng N,Aakre ME,Yi Y,Eng J,Link AJ,Moses HL

Thu Jul 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: epididymis luminal protein 107; epididymis secretory protein Li 48; P68; TK; Transketolase

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Gene Aliases: HEL-S-48; HEL107; p68; TK; TKT; TKT1

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UniProt ID: (Human) P29401, (Mouse) P40142, (Rat) P50137

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Entrez Gene ID: (Human) 7086, (Mouse) 21881, (Rat) 64524

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Function(s)

transketolase activity protein binding protein homodimerization activity metal ion binding cofactor binding magnesium ion binding catalytic activity transferase activity carbohydrate binding thiamine pyrophosphate binding monosaccharide binding

Process(es)

xylulose biosynthetic process pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch regulation of growth glyceraldehyde-3-phosphate biosynthetic process metabolic process ribose phosphate biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Transketolase Polyclonal Antibody

Transketolase Antibody (11039-1-AP) in ICC/IF

Product Details

11039-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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