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Invitrogen
Triadin Polyclonal Antibody
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Product Details
PA5-58304
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Triadin. Recombinant protein control fragment (Product #RP-95726).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648904
Product Specific Information
Immunogen sequence: VSTRKESLQL HNVTKAEKPA RVSKDVEDVP ASKKAKEGTE DVSPTKQKSP ISFFQCVYLD GYNGYGFQFP
Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 60%.
Target Information
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR’s) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR’s), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR’s and RyR’s. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Triadin
Gene Aliases: CPVT5; TDN; TRDN; TRISK
UniProt ID: (Human) Q13061
Entrez Gene ID: (Human) 10345
cellular calcium ion homeostasis
muscle contraction
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cytoplasmic microtubule organization
ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
heart contraction
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell membrane potential
endoplasmic reticulum membrane organization
positive regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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