Product References
Quantification of the calcium signaling deficit in muscles devoid of triadin.
PloS one
Manno C,Tammineni E,Figueroa L,Marty I,Ríos E
MA3-927 was used in ELISA, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to find higher resting cytosolic and lower SR-luminal [Ca2+], 40% lower calsequestrin expression, and more CaV1.1, RyR1 and SERCA1.
Wed Mar 09 00:00:00 UTC 2022
Quantification of the calcium signaling deficit in muscles devoid of triadin.
PloS one
Manno C,Tammineni E,Figueroa L,Marty I,Ríos E
MA3-927 was used in ELISA, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to find higher resting cytosolic and lower SR-luminal [Ca2+], 40% lower calsequestrin expression, and more CaV1.1, RyR1 and SERCA1.
Wed Mar 09 00:00:00 UTC 2022
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Nature communications
Estañ MC,Fernández-Núñez E,Zaki MS,Esteban MI,Donkervoort S,Hawkins C,Caparros-Martin JA,Saade D,Hu Y,Bolduc V,Chao KR,Nevado J,Lamuedra A,Largo R,Herrero-Beaumont G,Regadera J,Hernandez-Chico C,Tizzano EF,Martinez-Glez V,Carvajal JJ,Zong R,Nelson DL,Otaify GA,Temtamy S,Aglan M,Issa M,Bönnemann CG,Lapunzina P,Yoon G,Ruiz-Perez VL
MA3-927 was used in Western Blotting to study how recessive mutations in exon-15 of FXR1 cause congenital multi-minicore myopathy in humans and mice.
Fri Feb 15 00:00:00 UTC 2019
A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Nature communications
Lee CS,Hanna AD,Wang H,Dagnino-Acosta A,Joshi AD,Knoblauch M,Xia Y,Georgiou DK,Xu J,Long C,Amano H,Reynolds C,Dong K,Martin JC,Lagor WR,Rodney GG,Sahin E,Sewry C,Hamilton SL
MA3927 was used in western blot to elucidate the mechanism by which the I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel results in disease
Fri Mar 24 00:00:00 UTC 2017
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Nature communications
Cerrone M,Montnach J,Lin X,Zhao YT,Zhang M,Agullo-Pascual E,Leo-Macias A,Alvarado FJ,Dolgalev I,Karathanos TV,Malkani K,Van Opbergen CJM,van Bavel JJA,Yang HQ,Vasquez C,Tester D,Fowler S,Liang F,Rothenberg E,Heguy A,Morley GE,Coetzee WA,Trayanova NA,Ackerman MJ,van Veen TAB,Valdivia HH,Delmar M
MA3-927 was used in Immunohistochemistry to show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart.
Mon Jul 24 00:00:00 UTC 2017
Transitions of protein traffic from cardiac ER to junctional SR.
Journal of molecular and cellular cardiology
Sleiman NH,McFarland TP,Jones LR,Cala SE
MA3-927 was used in immunocytochemistry and western blot to study cellular mechanisms for sorting and trafficking proteins to junctional sarcoplasmic reticulum
Wed Apr 01 00:00:00 UTC 2015
Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.
FEBS letters
Van B,Nishi M,Komazaki S,Ichimura A,Kakizawa S,Nakanaga K,Aoki J,Park KH,Ma J,Ueyama T,Ogata T,Maruyama N,Takeshima H
MA3-927 was used in western blot to investigate Mitsugumin 56 in skeletal muscle maturation using knockout mice
Tue Apr 28 00:00:00 UTC 2015
Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.
FEBS letters
Van B,Nishi M,Komazaki S,Ichimura A,Kakizawa S,Nakanaga K,Aoki J,Park KH,Ma J,Ueyama T,Ogata T,Maruyama N,Takeshima H
MA3-927 was used in western blot to investigate Mitsugumin 56 in skeletal muscle maturation using knockout mice
Tue Apr 28 00:00:00 UTC 2015
Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.
The Journal of biological chemistry
Desmond PF,Muriel J,Markwardt ML,Rizzo MA,Bloch RJ
MA3-927 was used in western blot to test if sAnk and SERCA interact.
Fri Nov 13 00:00:00 UTC 2015
Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.
PloS one
Boncompagni S,Thomas M,Lopez JR,Allen PD,Yuan Q,Kranias EG,Franzini-Armstrong C,Perez CF
MA3-927 was used in western blot to study the roles of triadin and junctin in anchoring calsequestrin to the junctional sarcoplasmic reticulum and in Ca(2+) homeostasis using triadin/junctin (-/-) knockout mice
Tue Nov 13 00:00:00 UTC 2012
Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.
Journal of lipid research
Jeppesen J,Albers PH,Rose AJ,Birk JB,Schjerling P,Dzamko N,Steinberg GR,Kiens B
MA3-927 was used in western blot to investigate the mechanism of FAT/CD36 trafficking and FA uptake in skeletal muscles during contraction
Fri Apr 01 00:00:00 UTC 2011
Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.
Journal of molecular biology
Ojima K,Ono Y,Ottenheijm C,Hata S,Suzuki H,Granzier H,Sorimachi H
MA3-927 was used in western blot to study the localization and function of calpain-3 in sarcoplasmic reticulum
Fri Apr 01 00:00:00 UTC 2011
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.
American journal of physiology. Heart and circulatory physiology
Han P,Cai W,Wang Y,Lam CK,Arvanitis DA,Singh VP,Chen S,Zhang H,Zhang R,Cheng H,Kranias EG
MA3-927 was used in western blot to investigate the relationship between histidine-rich calcium binding protein HRC S96A variant overexpression and human arrhythmias
Sat Oct 01 00:00:00 UTC 2011
Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.
Cell calcium
Eltit JM,Szpyt J,Li H,Allen PD,Perez CF
Tue Feb 01 00:00:00 UTC 2011
Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.
Cell calcium
Eltit JM,Szpyt J,Li H,Allen PD,Perez CF
Tue Feb 01 00:00:00 UTC 2011
Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+.
The Journal of biological chemistry
Eltit JM,Feng W,Lopez JR,Padilla IT,Pessah IN,Molinski TF,Fruen BR,Allen PD,Perez CF
MA3-927 was used in western blot to investigate the importance of triadins in the regulation of resting cytoplasmic calcium
Fri Dec 03 00:00:00 UTC 2010
Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+.
The Journal of biological chemistry
Eltit JM,Feng W,Lopez JR,Padilla IT,Pessah IN,Molinski TF,Fruen BR,Allen PD,Perez CF
MA3-927 was used in western blot to investigate the importance of triadins in the regulation of resting cytoplasmic calcium
Fri Dec 03 00:00:00 UTC 2010
Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model.
Circulation research
Rizzi N,Liu N,Napolitano C,Nori A,Turcato F,Colombi B,Bicciato S,Arcelli D,Spedito A,Scelsi M,Villani L,Esposito G,Boncompagni S,Protasi F,Volpe P,Priori SG
MA3-927 was used in western blot to investigate the structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin in a homozygous CASQ2 (R33Q/R33Q) knock in mouse model
Fri Aug 01 00:00:00 UTC 2008
Regulation and function of Ca2+-calmodulin-dependent protein kinase II of fast-twitch rat skeletal muscle.
The Journal of physiology
Rose AJ,Alsted TJ,Kobberø JB,Richter EA
MA3-927 was used in western blot to study the regulation and function of CaMKII during exercise/contraction in rat skeletal muscle.
Tue May 01 00:00:00 UTC 2007
Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle.
The Journal of biological chemistry
Shen X,Franzini-Armstrong C,Lopez JR,Jones LR,Kobayashi YM,Wang Y,Kerrick WG,Caswell AH,Potter JD,Miller T,Allen PD,Perez CF
MA3-927 was used in Western Blotting to investigate how the absence of triadin expression affected the contractile function of skeletal muscle in mice.
Fri Dec 28 00:00:00 UTC 2007
Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle.
The Journal of biological chemistry
Shen X,Franzini-Armstrong C,Lopez JR,Jones LR,Kobayashi YM,Wang Y,Kerrick WG,Caswell AH,Potter JD,Miller T,Allen PD,Perez CF
MA3-927 was used in Western Blotting to investigate how the absence of triadin expression affected the contractile function of skeletal muscle in mice.
Fri Dec 28 00:00:00 UTC 2007
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.
The Journal of biological chemistry
Phimister AJ,Lango J,Lee EH,Ernst-Russell MA,Takeshima H,Ma J,Allen PD,Pessah IN
MA3-927 was used in immunoprecipitation to investigate the physical interaction between junctophilin 1 and ryanodine receptor type 1.
Fri Mar 23 00:00:00 UTC 2007
Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein.
Molecular and cellular biology
Jaehnig EJ,Heidt AB,Greene SB,Cornelissen I,Black BL
MA3-927 was used in western blot to investigate the role of HRCBP in sarcoplasmic reticulum (SR) calcium handling
Fri Dec 01 00:00:00 UTC 2006
Microarray profiling of skeletal muscle sarcoplasmic reticulum proteins.
Biochimica et biophysica acta
Schulz JS,Palmer N,Steckelberg J,Jones SJ,Zeece MG
MA3-927 was used in western blot to investigate the skeletal muscle sarcoplasmic reticulum proteins through microarray analyses
Fri Sep 01 00:00:00 UTC 2006
Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle.
American journal of physiology. Cell physiology
Perez CF,López JR,Allen PD
MA3-927 was used in western blot to investigate the effect of the transient expression of ryanodine receptor (RyR) type 3 and 1 on calcium homeostasis in skeletal muscle
Tue Mar 01 00:00:00 UTC 2005
Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle.
The Journal of cell biology
Protasi F,Franzini-Armstrong C,Allen PD
MA3-927 was used in immunohistochemistry to investigate the important roles of RyRs in assembling skeletal muscle's calcium release units
Mon Feb 23 00:00:00 UTC 1998
Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice.
The Journal of biological chemistry
Sato Y,Ferguson DG,Sako H,Dorn GW,Kadambi VJ,Yatani A,Hoit BD,Walsh RA,Kranias EG
MA3-927 was used in immunohistochemistry to demonstrate that calsequestrin overexpression is associated with depressed cardiovascular function and hypertrophy in transgenic mice
Fri Oct 23 00:00:00 UTC 1998
Effects of anti-triadin antibody on Ca2+ release from sarcoplasmic reticulum.
FEBS letters
Brandt NR,Caswell AH,Brunschwig JP,Kang JJ,Antoniu B,Ikemoto N
MA3-927 was used in blocking/activating experiment to investigate the effect of triadin blockade on calcium release from sarcoplasmic reticulum
Tue Mar 24 00:00:00 UTC 1992
