Invitrogen

Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (SN59-03)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-45024

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN59-03

Immunogen

Synthetic peptide within C-terminal human Tyrosine Hydroxylase.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931478

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase

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Gene Aliases: DYT14; DYT5b; TH; The; TYH

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UniProt ID: (Human) P07101, (Mouse) P24529, (Rat) P04177

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Entrez Gene ID: (Human) 7054, (Mouse) 21823, (Rat) 25085

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Function(s)
tyrosine 3-monooxygenase activity protein binding ferrous iron binding ferric iron binding amino acid binding oxygen binding enzyme binding protein domain specific binding tetrahydrobiopterin binding dopamine binding monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen metal ion binding
Process(es)
response to hypoxia synaptic transmission, dopaminergic dopamine biosynthetic process from tyrosine heart development visual perception learning memory mating behavior locomotory behavior regulation of heart contraction aromatic amino acid family metabolic process organ morphogenesis aminergic neurotransmitter loading into synaptic vesicle neurotransmitter biosynthetic process dopamine biosynthetic process epinephrine biosynthetic process norepinephrine biosynthetic process catecholamine biosynthetic process eye photoreceptor cell development eating behavior response to ethanol embryonic camera-type eye morphogenesis oxidation-reduction process response to amphetamine heart morphogenesis fatty acid metabolic process sphingolipid metabolic process sensory perception of sound response to water deprivation response to light stimulus response to herbicide response to salt stress anatomical structure morphogenesis response to zinc ion multicellular organism aging response to activity glycoside metabolic process phthalate metabolic process cerebral cortex development response to nutrient levels response to estradiol response to lipopolysaccharide isoquinoline alkaloid metabolic process social behavior cellular response to drug response to isolation stress response to immobilization stress terpene metabolic process circadian sleep/wake cycle response to peptide hormone pigmentation response to ether response to pyrethroid response to corticosterone response to electrical stimulus phytoalexin metabolic process cellular response to manganese ion cellular response to nicotine cellular response to glucose stimulus cellular response to growth factor stimulus response to metal ion response to organic cyclic compound response to insecticide response to nicotine response to drug response to steroid hormone cognition protein homotetramerization response to growth factor cellular response to alkaloid
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