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Proteintech
UACA Polyclonal Antibody
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Product Details
25654-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UACA Fusion Protein Ag22438 (1075-1416 aa encoded by BC113407)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LSQKYTEVK NVKEKLVEEN AKQTSEILAV QNLLQKQHVP LEQVEALKKS LNGTIENLKE ELKSMQRCYE KEQQTVTKLH QLLENQKNSS VPLAEHLQIK EAFEKEVGII KASLREKEEE SQNKMEEVSK LQSEVQNTKQ ALKKLETREV VDLSKYKATK SDLETQISSL NEKLANLNRK YEEVCEEVLH AKKKEISAKD EKELLHFSIE QEIKDQKERC DKSLTTITEL QRRIQESAKQ IEAKDNKITE LLNDVERLKQ ALNGLSQLTY TSGNPTKRQS QLIDTLQHQV KSLEQQLADA DRQHQEVIAI YRTHLLSAAQ GHMDEDVQEA LLQIIQMRQG LVC (1075-1416 aa encoded by BC113407)
Target Information
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: nuclear membrane binding protein; nuclear membrane binding protein NUCLING; Nuclear membrane-binding protein; Nucling; uveal autoantigen with coiled coil domains and ankyrin repeats; Uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene Aliases: 2700059D02Rik; KIAA1561; NUCLING; UACA
UniProt ID: (Human) Q9BZF9, (Mouse) Q8CGB3
Entrez Gene ID: (Human) 55075, (Mouse) 72565
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
positive regulation of protein import into nucleus
negative regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of inflammatory response
apoptotic signaling pathway
regulation of NIK/NF-kappaB signaling
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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