Proteintech

UBASH3B/STS 1 Polyclonal Antibody

UBASH3B/STS 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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UBASH3B/STS 1 Antibody (19563-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human hepatocirrhosis using 19563-1-AP (UBASH3B/STS 1 antibody) at dilution of 1:100 (under 40x lens).

UBASH3B/STS 1 Antibody in Western Blot (WB)

UBASH3B/STS 1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19563-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

Sts1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.

International journal of molecular sciences

Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L

Fri Feb 03 00:00:00 UTC 2023

PSGL-1 attenuates early TCR signaling to suppress CD8⁺ T cell progenitor differentiation and elicit terminal CD8⁺ T cell exhaustion.

Cell reports

Hope JL,Otero DC,Bae EA,Stairiker CJ,Palete AB,Faso HA,Lin M,Henriquez ML,Roy S,Seo H,Lei X,Wang ES,Chow S,Tinoco R,Daniels GA,Yip K,Campos AR,Yin J,Adams PD,Rao A,Bradley LM

Tue May 30 00:00:00 UTC 2023

PSGL-1 attenuates early TCR signaling to suppress CD8⁺ T cell progenitor differentiation and elicit terminal CD8⁺ T cell exhaustion.

Cell reports

Hope JL,Otero DC,Bae EA,Stairiker CJ,Palete AB,Faso HA,Lin M,Henriquez ML,Roy S,Seo H,Lei X,Wang ES,Chow S,Tinoco R,Daniels GA,Yip K,Campos AR,Yin J,Adams PD,Rao A,Bradley LM

Tue May 30 00:00:00 UTC 2023

PSGL-1 attenuates early TCR signaling to suppress CD8⁺ T cell progenitor differentiation and elicit terminal CD8⁺ T cell exhaustion.

Cell reports

Hope JL,Otero DC,Bae EA,Stairiker CJ,Palete AB,Faso HA,Lin M,Henriquez ML,Roy S,Seo H,Lei X,Wang ES,Chow S,Tinoco R,Daniels GA,Yip K,Campos AR,Yin J,Adams PD,Rao A,Bradley LM

Tue May 30 00:00:00 UTC 2023

PSGL-1 attenuates early TCR signaling to suppress CD8⁺ T cell progenitor differentiation and elicit terminal CD8⁺ T cell exhaustion.

Cell reports

Hope JL,Otero DC,Bae EA,Stairiker CJ,Palete AB,Faso HA,Lin M,Henriquez ML,Roy S,Seo H,Lei X,Wang ES,Chow S,Tinoco R,Daniels GA,Yip K,Campos AR,Yin J,Adams PD,Rao A,Bradley LM

Tue May 30 00:00:00 UTC 2023

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.

Frontiers in immunology

Monticone G,Huang Z,Csibi F,Leit S,Ciccone D,Champhekar AS,Austin JE,Ucar DA,Hossain F,Ibba SV,Boulares AH,Carpino N,Xu K,Majumder S,Osborne BA,Loh C,Miele L

Tue Sep 13 00:00:00 UTC 2022

Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.

Biochimie

Yao Y,Liu W,Gajendran B,Wang C,Zacksenhaus E,Sample KM,Varier KM,Hao X,Ben-David Y

Sat May 01 00:00:00 UTC 2021

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.

Cell

Lundby A,Franciosa G,Emdal KB,Refsgaard JC,Gnosa SP,Bekker-Jensen DB,Secher A,Maurya SR,Paul I,Mendez BL,Kelstrup CD,Francavilla C,Kveiborg M,Montoya G,Jensen LJ,Olsen JV

Thu Oct 03 00:00:00 UTC 2019

Inhibition of T cell activation and function by the adaptor protein CIN85.

Science signaling

Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T

Tue Feb 05 00:00:00 UTC 2019

Prazosin inhibits the growth and mobility of osteosarcoma cells.

Translational cancer research

An M,Ma WH,Jia HW,Li YW,Feng JJ,Meng J,Qi H,Liu J

Sun Sep 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Cbl-interacting protein p70; Cbl-interacting protein Sts-1; MGC15437; nm23-phosphorylated unknown substrate; SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate; STS-1; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2; Ubiquitin-associated and SH3 domain-containing protein B

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Gene Aliases: 2810457I06Rik; BB125008; KIAA1959; p70; RGD1310357; STS-1; STS1; TULA-2; TULA2; UBASH3B

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UniProt ID: (Human) Q8TF42, (Mouse) Q8BGG7

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Entrez Gene ID: (Human) 84959, (Mouse) 72828, (Rat) 315579

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Function(s)

protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity

Process(es)

negative regulation of protein kinase activity negative regulation of signal transduction peptidyl-tyrosine dephosphorylation negative regulation of osteoclast differentiation negative regulation of bone resorption regulation of release of sequestered calcium ion into cytosol negative regulation of platelet aggregation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UBASH3B/STS 1 Polyclonal Antibody

UBASH3B/STS 1 Antibody (19563-1-AP) in IHC (P)

Product Details

19563-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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