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Product Details
PA5-17592
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat,
Xenopus,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids at the amino-terminus of human HR6A
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10981771
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2 protein; E2 ubiquitin-conjugating enzyme A; E2 ubiquitin-conjugating enzyme B; E2(14k); E214K; HR6A; HR6B; RAD6 homolog A; RAD6 homolog B; Ubiquitin carrier protein A; Ubiquitin carrier protein B; ubiquitin conjugating enzyme; ubiquitin conjugating enzyme E2A; ubiquitin conjugating enzyme E2B; Ubiquitin-conjugating enzyme E2 A; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2(14k); Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-conjugating enzyme E2A, RAD6 homolog; ubiquitin-conjugating enzyme E2B (RAD6 homolog); ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae); ubiquitin-conjugating enzyme E2B, RAD6 homolog; ubiquitin-conjugating enzyme E2B, RAD6 homology; ubiquitin-conjugating enzyme HR6A; Ubiquitin-protein ligase A; Ubiquitin-protein ligase B
Gene Aliases: 2610301N02Rik; E2-14k; E2-17kDa; HHR6A; HHR6B; HR6A; HR6B; Mhr6a; mHR6B; mp:zf637-2-000771; MRXS30; MRXSN; RAD6A; RAD6B; si:bz46j2.4; UBC2; UBCH1; UBE2A; UBE2B; wu:fa01h11; zgc:100921
UniProt ID: (Human) P49459, (Human) P63146, (Mouse) Q9Z255, (Rat) P63149, (Mouse) P63147
Entrez Gene ID: (Chicken) 395672, (Human) 7319, (Human) 7320, (Rat) 298317, (Mouse) 22209, (Rat) 81816, (Mouse) 22210, (Zebrafish) 797853, (Zebrafish) 437020
ubiquitin-protein transferase activity
protein binding
ATP binding
ubiquitin protein ligase binding
ubiquitin binding
ubiquitin protein ligase activity
ubiquitin conjugating enzyme activity
molecular_function
ligase activity
ubiquitin-like protein transferase activity
nucleotide binding
transferase activity
protein polyubiquitination
response to hypoxia
in utero embryonic development
DNA repair
postreplication repair
maintenance of chromatin silencing
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
spermatogenesis
sperm axoneme assembly
response to UV
positive regulation of reciprocal meiotic recombination
protein ubiquitination
histone ubiquitination
regulation of histone modification
cellular response to insulin stimulus
negative regulation of histone phosphorylation
histone H2A ubiquitination
response to drug
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cAMP-mediated signaling
protein stabilization
chiasma assembly
protein autoubiquitination
canonical Wnt signaling pathway
histone lysine demethylation
synaptonemal complex organization
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
biological_process
positive regulation of cell proliferation
maternal process involved in female pregnancy
DNA damage response, detection of DNA damage
meiotic telomere clustering
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