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Invitrogen
UBE2V2 Polyclonal Antibody
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Product Details
PA5-30994
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human MMS2 Recombinant protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548468
Product Specific Information
Recommended positive controls: HL-60, BCL-1.
Predicted reactivity: Mouse (98%), Rat (99%), Zebrafish (93%), Xenopus laevis (91%), Dog (100%), Pig (99%), Chicken (98%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1 alpha,25-dihydroxyvitamin D3-inducible; DDVit 1; EDAF-1; EDPF-1; enterocyte differentiation promoting factor; Enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; Enterocyte differentiation-promoting factor 1; meth; methyl methanesulfonate sensitive 2; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of; MMS2 homolog; Ubc-like protein MMS2; ubiquitin conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme E2 variant 2; Vitamin D3-inducible protein
Gene Aliases: 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UBE2V2; UEV-2; UEV2
UniProt ID: (Human) Q15819, (Mouse) Q9D2M8
Entrez Gene ID: (Human) 7336, (Mouse) 70620
DNA double-strand break processing
positive regulation of neuron projection development
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
error-free postreplication DNA repair
negative regulation of neuron apoptotic process
positive regulation of DNA repair
positive regulation of synapse assembly
protein K63-linked ubiquitination
protein polyubiquitination
regulation of DNA repair
postreplication repair
double-strand break repair via nonhomologous end joining
cell proliferation
protein ubiquitination
global genome nucleotide-excision repair
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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