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          • Primary Antibodies ›
          • UBE2V2 Antibodies

          Invitrogen

          UBE2V2 Polyclonal Antibody

          View all (11) UBE2V2 antibodies
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          Cite UBE2V2 Polyclonal Antibody

          • Antibody Testing Data (2)
          UBE2V2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          UBE2V2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 2

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          UBE2V2 Antibody (PA5-93337) in IHC (P)

          Immunohistochemistry analysis of UBE2V2 in paraffin-embedded rat spleen. Samples were incubated with UBE2V2 Polyclonal antibody (Product # PA5-93337) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          UBE2V2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          UBE2V2 Antibody in Western Blot (WB)

          Product Details

          PA5-93337

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          ELISA (ELISA)

          1 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_0033411)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.68 mg/mL

          Purification

          Affinity Chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Wet ice

          RRID

          AB_2806723

          Product Specific Information

          Immunogen sequence: MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN; Positive Samples: SW480, SKOV3, HeLa, HL-60, Mouse liver, Mouse skin, Rat liver, Rat brain

          Target Information

          The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: 1 alpha,25-dihydroxyvitamin D3-inducible; DDVit 1; EDAF-1; EDPF-1; enterocyte differentiation promoting factor; Enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; Enterocyte differentiation-promoting factor 1; meth; methyl methanesulfonate sensitive 2; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of; MMS2 homolog; Ubc-like protein MMS2; ubiquitin conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2v2; Ubiquitin-conjugating enzyme variant MMS2; Vitamin D3-inducible protein

          View more View less

          Gene Aliases: 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UBE2V2; UEV-2; UEV2

          View more View less

          UniProt ID: (Human) Q15819, (Rat) Q7M767, (Mouse) Q9D2M8

          View more View less

          Entrez Gene ID: (Human) 7336, (Rat) 287927, (Mouse) 70620

          View more View less

          Function(s)
          protein binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin conjugating enzyme activity molecular_function ubiquitin-like protein transferase activity
          Process(es)
          DNA double-strand break processing postreplication repair positive regulation of neuron projection development positive regulation of proteasomal ubiquitin-dependent protein catabolic process error-free postreplication DNA repair negative regulation of neuron apoptotic process positive regulation of DNA repair positive regulation of synapse assembly protein K63-linked ubiquitination protein polyubiquitination regulation of DNA repair double-strand break repair via nonhomologous end joining cell proliferation protein ubiquitination global genome nucleotide-excision repair
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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