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Bioss
UCHL1+3 Polyclonal Antibody
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FIGURE: 1 / 4
UCHL1+3 Antibody (BS-11677R) in WB
Lane 1: Mouse Hippocampus lysates; Lane 2: Mouse Cerebellum lysates; Lane 3: Mouse Cerebrum lysates probed with UCHL1+3 Polyclonal Antibody, Unconjugated (bs-11677R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-11677R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human UCHL1+3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The two ubiquitin C-terminal hydrolase (UCH) enzymes, UCHL1 and UCHL3, deubiquitinate ubiquitin-protein conjugates and control the cellular balance of ubiquitin. UCHL1 and UCHL3 are both small proteins of ~220 amino acids that share more than 40% amino acid sequence identity. UCHL3 is universally expressed in all tissues, while UCHL1 is expressed exclusively in neuronal tissue, testis and ovary. The activity of UCHL3 is more than 200 fold higher than UCHL1 when a fluorogenic ubiquitin substrate is used. UCHL1 associates with monoubiquitin and UCHL3 binds to Nedd8, ubiquitin-like protein. UCHL1 and UCHL3 play a role in the regulation of neuronal development and spermatogenesis. UCHL1 is involved in the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis luminal protein 117; epididymis secretory protein Li 53; gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; protein gene product 9.5; ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; ubiquitin thiolesterase; UCH-L1
Gene Aliases: AW822034; C88048; gad; HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; R75593; UCH-L1; UCHL-1; UCHL1
UniProt ID: (Human) P09936, (Mouse) Q9R0P9, (Rat) Q00981
Entrez Gene ID: (Human) 7345, (Mouse) 22223, (Rat) 29545
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
omega peptidase activity
ligase activity
ubiquitin protein ligase binding
alpha-2A adrenergic receptor binding
ubiquitin binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
response to ischemia
proteolysis
ubiquitin-dependent protein catabolic process
axonogenesis
axon target recognition
adult walking behavior
cell proliferation
protein deubiquitination
sensory perception of pain
axonal transport of mitochondrion
eating behavior
negative regulation of MAP kinase activity
muscle fiber development
neuromuscular process
regulation of macroautophagy
proteasome-mediated ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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