Proteintech

UCK2 Polyclonal Antibody

FIGURE: 1 / 3

UCK2 Antibody (10511-1-AP) in WB

Jurkat cells were subjected to SDS PAGE followed by western blot with 10511-1-AP (UCK2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

UCK2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10511-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UCK2 Fusion Protein Ag0782 (1-261 aa encoded by BC002906)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.55 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAGDSEQTL QNHQQPNGGE PFLIGVSGGT ASGKSSVCAK IVQLLGQNEV DYRQKQVVIL SQDSFYRVLT SEQKAKALKG QFNFDHPDAF DNELILKTLK EITEGKTVQI PVYDFVSHSR KEETVTVYPA DVVLFEGILA FYSQEVRDLF QMKLFVDTDA DTRLSRRVLR DISERGRDLE QILSQYITFV KPAFEEFCLP TKKYADVIIP RGADNLVAIN LIVQHIQDIL NGGPSKRQTN GCLNGYTPSR KRQASESSSR PH (1-261 aa encoded by BC002906)

Target Information

UCK2 catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Oncogene-like addiction to aneuploidy in human cancers.

bioRxiv : the preprint server for biology

Girish V,Lakhani AA,Scaduto CM,Thompson SL,Brown LM,Hagenson RA,Sausville EL,Mendelson BE,Lukow DA,Yuan ML,Kandikuppa PK,Stevens EC,Lee SN,Salovska B,Li W,Smith JC,Taylor AM,Martienssen RA,Liu Y,Sun R,Sheltzer JM

Tue Jan 10 00:00:00 UTC 2023

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.

Nature metabolism

Skinner OS,Blanco-Fernández J,Goodman RP,Kawakami A,Shen H,Kemény LV,Joesch-Cohen L,Rees MG,Roth JA,Fisher DE,Mootha VK,Jourdain AA

Mon May 01 00:00:00 UTC 2023

A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.

Cell reports

Boukouris AE,Zhang Y,Saleme B,Kinnaird A,Zhao YY,Liu Y,Zervopoulos SD,Das SK,Mittal RD,Haromy A,Lorenzana-Carrillo MA,Krysler AR,Cromwell CR,Hubbard BP,Sutendra G,Michelakis ED

Tue Mar 15 00:00:00 UTC 2022

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.

Cancer cell

Pal S,Kaplan JP,Nguyen H,Stopka SA,Savani MR,Regan MS,Nguyen QD,Jones KL,Moreau LA,Peng J,Dipiazza MG,Perciaccante AJ,Zhu X,Hunsel BR,Liu KX,Alexandrescu S,Drissi R,Filbin MG,McBrayer SK,Agar NYR,Chowdhury D,Haas-Kogan DA

Mon Sep 12 00:00:00 UTC 2022

Adult T-cell leukemia-lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism.

International journal of cancer

Yoshida-Sakai N,Watanabe T,Yamamoto Y,Ureshino H,Kamachi K,Kurahashi Y,Fukuda-Kurahashi Y,Kimura S

Fri Apr 01 00:00:00 UTC 2022

Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.

Cell proliferation

Wang Z,Fu Y,Xia A,Chen C,Qu J,Xu G,Zou X,Wang Q,Wang S

Fri Oct 01 00:00:00 UTC 2021

Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.

Cell proliferation

Wang Z,Fu Y,Xia A,Chen C,Qu J,Xu G,Zou X,Wang Q,Wang S

Fri Oct 01 00:00:00 UTC 2021

Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.

Cancer management and research

Zhou Q,Jiang H,Zhang J,Yu W,Zhou Z,Huang P,Wang J,Xiao Z

Wed Mar 30 00:00:00 UTC 2022

Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.

Cancer management and research

Zhou Q,Jiang H,Zhang J,Yu W,Zhou Z,Huang P,Wang J,Xiao Z

Wed Mar 30 00:00:00 UTC 2022

Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.

Cancer management and research

Zhou Q,Jiang H,Zhang J,Yu W,Zhou Z,Huang P,Wang J,Xiao Z

Wed Mar 30 00:00:00 UTC 2022

Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.

Cancer management and research

Zhou Q,Jiang H,Zhang J,Yu W,Zhou Z,Huang P,Wang J,Xiao Z

Wed Mar 30 00:00:00 UTC 2022

Lack of cross-resistance to FF-10501, an inhibitor of inosine-5'-monophosphate dehydrogenase, in azacitidine-resistant cell lines selected from SKM-1 and MOLM-13 leukemia cell lines.

Pharmacology research & perspectives

Murase M,Iwamura H,Komatsu K,Saito M,Maekawa T,Nakamura T,Yokokawa T,Shimada Y

Mon Feb 01 00:00:00 UTC 2016

Lack of cross-resistance to FF-10501, an inhibitor of inosine-5'-monophosphate dehydrogenase, in azacitidine-resistant cell lines selected from SKM-1 and MOLM-13 leukemia cell lines.

Pharmacology research & perspectives

Murase M,Iwamura H,Komatsu K,Saito M,Maekawa T,Nakamura T,Yokokawa T,Shimada Y

Mon Feb 01 00:00:00 UTC 2016

Mechanisms of resistance to azacitidine in human leukemia cell lines.

Experimental hematology

Sripayap P,Nagai T,Uesawa M,Kobayashi H,Tsukahara T,Ohmine K,Muroi K,Ozawa K

Tue Apr 01 00:00:00 UTC 2014

Mechanisms of resistance to azacitidine in human leukemia cell lines.

Experimental hematology

Sripayap P,Nagai T,Uesawa M,Kobayashi H,Tsukahara T,Ohmine K,Muroi K,Ozawa K

Tue Apr 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Cytidine monophosphokinase 2; Testis-specific protein TSA903; UCK 2; uridine kinase; uridine monophosphate kinase; Uridine monophosphokinase 2; Uridine-cytidine kinase 2

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Gene Aliases: TSA903; UCK2; UK; UMPK

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UniProt ID: (Human) Q9BZX2

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Entrez Gene ID: (Human) 7371

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Function(s)

uridine kinase activity ATP binding nucleoside kinase activity

Process(es)

pyrimidine nucleobase metabolic process CMP salvage phosphorylation pyrimidine nucleoside salvage UMP salvage CTP salvage

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UCK2 Polyclonal Antibody

UCK2 Antibody (10511-1-AP) in WB

Product Details

10511-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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