Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
UCP2 Monoclonal Antibody (2B4B1)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
66700-1-IG
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
2B4B1
Immunogen
UCP2 Fusion Protein Ag19361 (1-309 aa encoded by BC011737)
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detect a band around 28-33 kDa corresponding to UCP2 protein in mouse liver, skeletal muscle and pancreas. Some upper and lower bands also were observed due to the dimer formation and degradation of the UCP2 protein. This antibody was raised against the full-length UCP2 protein and may cross-react with UCP3. It is notable that UCP2 is known to have a very short half-life less than 1 hour. It is strongly recommended that fresh-made lysate be used for western blot assays.
Immunogen sequence: MVGFKATDV PPTATVKFLG AGTAACIADL ITFPLDTAKV RLQIQGESQG PVRATASAQY RGVMGTILTM VRTEGPRSLY NGLVAGLQRQ MSFASVRIGL YDSVKQFYTK GSEHASIGSR LLAGSTTGAL AVAVAQPTDV VKVRFQAQAR AGGGRRYQST VNAYKTIARE EGFRGLWKGT SPNVARNAIV NCAELVTYDL IKDALLKANL MTDDLPCHFT SAFGAGFCTT VIASPVDVVK TRYMNSALGQ YSSAGHCALT MLQKEGPRAF YKGFMPSFLR LGSWNVVMFV TYEQLKRALM AACTSREAPF (1-309 aa encoded by BC011737)
Target Information
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Dicarboxylate carrier SLC25A8; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein; uncoupling protein 2 (mitochondrial, proton carrier)
Gene Aliases: BMIQ4; SLC25A8; UCP2; UCPH
UniProt ID: (Human) P55851
Entrez Gene ID: (Human) 7351
response to superoxide
response to hypoxia
translation
transport
mitochondrial transport
female pregnancy
aging
positive regulation of cell death
proton transport
cellular response to insulin stimulus
cellular response to amino acid starvation
negative regulation of apoptotic process
regulation of mitochondrial membrane potential
negative regulation of insulin secretion involved in cellular response to glucose stimulus
response to fatty acid
cellular response to glucose stimulus
liver regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support