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Invitrogen
UCP3 Polyclonal Antibody
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Product Details
PA1-24895
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human UCP-3 sequence (amino acids 254-267) with N-terminal lysine added, conjugated to KLH.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2257029
Product Specific Information
Recommended positive controls: human and mouse skeletal muscle, mitochondrial extract of rat brown adipose tissue.
The corresponding sequence in rat and mouse UCP3 differ by 4 and 3 amino acids respectively. This antibody exhibits no cross reactivity with UCP1 or UCP2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation. An additional UCP family member, UCP3, is highly muscle specific and is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mitochondrial uncoupling protein 3; Putative mitochondrial transporter UCP3; Solute carrier family 25 member 9; UCP 3; uncoupling protein; Uncoupling protein 3; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein 3, mitochondrial; Uncoupling protein-3
Gene Aliases: AI645527; SLC25A9; UCP-3; UCP3
UniProt ID: (Human) P55916, (Mouse) P56501, (Rat) P56499
Entrez Gene ID: (Human) 7352, (Mouse) 22229, (Rat) 25708
response to superoxide
response to hypoxia
translation
lipid metabolic process
fatty acid metabolic process
mitochondrial transport
aging
response to nutrient
respiratory gaseous exchange
response to cold
response to activity
proton transport
response to insulin
cellular response to hormone stimulus
response to glucocorticoid
transport
transmembrane transport
response to steroid hormone
hydrogen ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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